| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T225 |
0-140 |
Sentence |
denotes |
Few drugs have shown consistent antiviral efficiency in vitro together with reported efficiency in patients infected with SARS-CoV-2 [3,12]. |
| T226 |
141-268 |
Sentence |
denotes |
Of these, CLQ is of interest as its chemical structure is based on a combination of cationic nitrogen atoms and aromatic rings. |
| T227 |
269-394 |
Sentence |
denotes |
Both features have been shown to be key determinants of the recognition of sialic acids and gangliosides by proteins [20,26]. |
| T228 |
395-646 |
Sentence |
denotes |
Modelling approaches have been used successfully to decipher various molecular mechanisms of protein–sugar interactions accounting for the interaction of virus [27], bacteria [28], membrane [13] and amyloid proteins [20] with cell surface glycolipids. |
| T229 |
647-802 |
Sentence |
denotes |
This in-silico strategy was applied to unravel the molecular mechanisms underlying the antiviral mechanisms of CLQ and CLQ-OH against SARS-CoV-2 infection. |
| T230 |
803-963 |
Sentence |
denotes |
First, it was shown that CLQ and CLQ-OH bind readily to sialic acids with high affinity, including the typical 9-O-SIA subtype recognized by coronaviruses [23]. |
| T231 |
964-1052 |
Sentence |
denotes |
Next, it was shown that CLQ and CLQ-OH also bind to sialic-acid-containing gangliosides. |
| T232 |
1053-1145 |
Sentence |
denotes |
Based on these data, the drugs may also recognize the sialic acid residues of glycoproteins. |
| T233 |
1146-1191 |
Sentence |
denotes |
Further studies will help clarify this point. |
