| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T180 |
110-226 |
Sentence |
denotes |
The viral protein displays two distinct domains, the tips of which are available for distinct types of interactions. |
| T181 |
227-376 |
Sentence |
denotes |
The receptor-binding domain binds to the ACE-2 receptor, and the N-terminal domain (NTD) binds to the ganglioside-rich domain of the plasma membrane. |
| T182 |
377-610 |
Sentence |
denotes |
Lipid rafts, which are membrane domains enriched in gangliosides (in yellow) and cholesterol (in blue), provide a perfect attractive interface for adequately positioning the viral S protein at the first step of the infection process. |
| T183 |
611-867 |
Sentence |
denotes |
These structural and molecular modelling studies suggest that amino acid residues 111–162 of the NTD form a functional ganglioside-binding domain, the interaction of which with lipid rafts can be efficiently prevented by chloroquine and hydroxychloroquine. |
