PMC:7128678 / 19820-20600 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T168 0-108 Sentence denotes Fig. 7 Molecular complex between the N-terminal domain (NTD) of SARS-CoV-2 spike protein and a dimer of GM1.
T169 109-166 Sentence denotes In (a), (c) and (d), the NTD is represented as in Fig. 4.
T170 167-232 Sentence denotes In (b), the surface of the NTD is shown without any transparency.
T171 233-355 Sentence denotes The amino acid residues Q-134 to S-162 belonging to the ganglioside-binding domain (GBD) are represented as green spheres.
T172 356-465 Sentence denotes Compared with a single GM1 molecule, the dimer of gangliosides forms a larger attractive surface for the NTD.
T173 466-561 Sentence denotes In the above view of (d), the anchorage of the NTD to the gangliosides is particularly obvious.
T174 562-780 Sentence denotes As chloroquine also interacts with the saccharide part of GM1, its presence would clearly mask most of the landing surface available for the NTD, preventing attachment of the virus to the plasma membrane of host cells.