| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T3 |
0-134 |
Sentence |
denotes |
An escalating pandemic by the novel SARS-CoV-2 virus is impacting global health and effective therapeutic options are urgently needed. |
| T4 |
135-349 |
Sentence |
denotes |
We evaluated the in vitro antiviral effect of compounds that were previously reported to inhibit coronavirus replication and compounds that are currently under evaluation in clinical trials for SARS-CoV-2 patients. |
| T5 |
350-582 |
Sentence |
denotes |
We report the antiviral effect of remdesivir, lopinavir, homorringtonine, and emetine against SARS-CoV-2 virus in Vero E6 cells with the estimated 50% effective concentration at 23.15 μM, 26.63 μM, 2.55 μM and 0.46 μM, respectively. |
| T6 |
583-690 |
Sentence |
denotes |
Ribavirin or favipiravir that are currently evaluated under clinical trials showed no inhibition at 100 μM. |
| T7 |
691-854 |
Sentence |
denotes |
Synergy between remdesivir and emetine was observed, and remdesivir at 6.25 μM in combination with emetine at 0.195 μM may achieve 64.9% inhibition in viral yield. |
| T8 |
855-1018 |
Sentence |
denotes |
Combinational therapy may help to reduce the effective concentration of compounds below the therapeutic plasma concentrations and provide better clinical benefits. |
