| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T55 |
0-97 |
Sentence |
denotes |
Key Points Related to the Interplay between Covid-19 and the Renin–Angiotensin–Aldosterone System |
| T56 |
98-252 |
Sentence |
denotes |
• ACE2, an enzyme that physiologically counters RAAS activation, is the functional receptor to SARS-CoV-2, the virus responsible for the Covid-19 pandemic |
| T57 |
253-413 |
Sentence |
denotes |
• Select preclinical studies have suggested that RAAS inhibitors may increase ACE2 expression, raising concerns regarding their safety in patients with Covid-19 |
| T58 |
414-589 |
Sentence |
denotes |
• Insufficient data are available to determine whether these observations readily translate to humans, and no studies have evaluated the effects of RAAS inhibitors in Covid-19 |
| T59 |
590-739 |
Sentence |
denotes |
• Clinical trials are under way to test the safety and efficacy of RAAS modulators, including recombinant human ACE2 and the ARB losartan in Covid-19 |
| T60 |
740-938 |
Sentence |
denotes |
• Abrupt withdrawal of RAAS inhibitors in high-risk patients, including those who have heart failure or have had myocardial infarction, may result in clinical instability and adverse health outcomes |
| T61 |
939-1125 |
Sentence |
denotes |
• Until further data are available, we think that RAAS inhibitors should be continued in patients in otherwise stable condition who are at risk for, being evaluated for, or with Covid-19 |
