PMC:7120970 / 77-3886 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T2 0-14 Sentence denotes To the Editor:
T3 15-367 Sentence denotes The novel coronavirus (2019-nCoV) from Wuhan is currently causing concern in the medical community as the virus is spreading around the world.1 Since identification of the virus in late December 2019, the number of cases from China that have been imported into other countries is on the rise, and the epidemiologic picture is changing on a daily basis.
T4 368-534 Sentence denotes We are reporting a case of 2019-nCoV infection acquired outside Asia in which transmission appears to have occurred during the incubation period in the index patient.
T5 535-670 Sentence denotes A 33-year-old otherwise healthy German businessman (Patient 1) became ill with a sore throat, chills, and myalgias on January 24, 2020.
T6 671-759 Sentence denotes The following day, a fever of 39.1°C (102.4°F) developed, along with a productive cough.
T7 760-854 Sentence denotes By the evening of the next day, he started feeling better and went back to work on January 27.
T8 855-990 Sentence denotes Before the onset of symptoms, he had attended meetings with a Chinese business partner at his company near Munich on January 20 and 21.
T9 991-1080 Sentence denotes The business partner, a Shanghai resident, had visited Germany between January 19 and 22.
T10 1081-1416 Sentence denotes During her stay, she had been well with no signs or symptoms of infection but had become ill on her flight back to China, where she tested positive for 2019-nCoV on January 26 (index patient in Figure 1) (see Supplementary Appendix, available at NEJM.org, for details on the timeline of symptom development leading to hospitalization).
T11 1417-1475 Sentence denotes On January 27, she informed the company about her illness.
T12 1476-1642 Sentence denotes Contact tracing was started, and the above-mentioned colleague was sent to the Division of Infectious Diseases and Tropical Medicine in Munich for further assessment.
T13 1643-1685 Sentence denotes At presentation, he was afebrile and well.
T14 1686-1812 Sentence denotes He reported no previous or chronic illnesses and had no history of foreign travel within 14 days before the onset of symptoms.
T15 1813-2166 Sentence denotes Two nasopharyngeal swabs and one sputum sample were obtained and were found to be positive for 2019-nCoV on quantitative reverse-transcriptase–polymerase-chain-reaction (qRT-PCR) assay.2 Follow-up qRT-PCR assay revealed a high viral load of 108 copies per milliliter in his sputum during the following days, with the last available result on January 29.
T16 2167-2289 Sentence denotes On January 28, three additional employees at the company tested positive for 2019-nCoV (Patients 2 through 4 in Figure 1).
T17 2290-2415 Sentence denotes Of these patients, only Patient 2 had contact with the index patient; the other two patients had contact only with Patient 1.
T18 2416-2600 Sentence denotes In accordance with the health authorities, all the patients with confirmed 2019-nCoV infection were admitted to a Munich infectious diseases unit for clinical monitoring and isolation.
T19 2601-2683 Sentence denotes So far, none of the four confirmed patients show signs of severe clinical illness.
T20 2684-2771 Sentence denotes This case of 2019-nCoV infection was diagnosed in Germany and transmitted outside Asia.
T21 2772-2945 Sentence denotes However, it is notable that the infection appears to have been transmitted during the incubation period of the index patient, in whom the illness was brief and nonspecific.3
T22 2946-3102 Sentence denotes The fact that asymptomatic persons are potential sources of 2019-nCoV infection may warrant a reassessment of transmission dynamics of the current outbreak.
T23 3103-3282 Sentence denotes In this context, the detection of 2019-nCoV and a high sputum viral load in a convalescent patient (Patient 1) arouse concern about prolonged shedding of 2019-nCoV after recovery.
T24 3283-3398 Sentence denotes Yet, the viability of 2019-nCoV detected on qRT-PCR in this patient remains to be proved by means of viral culture.
T25 3399-3544 Sentence denotes Despite these concerns, all four patients who were seen in Munich have had mild cases and were hospitalized primarily for public health purposes.
T26 3545-3809 Sentence denotes Since hospital capacities are limited — in particular, given the concurrent peak of the influenza season in the northern hemisphere — research is needed to determine whether such patients can be treated with appropriate guidance and oversight outside the hospital.