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PMC:7120970 JSONTXT 19 Projects

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Id Subject Object Predicate Lexical cue
T1 0-75 Sentence denotes Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany
T2 77-91 Sentence denotes To the Editor:
T3 92-444 Sentence denotes The novel coronavirus (2019-nCoV) from Wuhan is currently causing concern in the medical community as the virus is spreading around the world.1 Since identification of the virus in late December 2019, the number of cases from China that have been imported into other countries is on the rise, and the epidemiologic picture is changing on a daily basis.
T4 445-611 Sentence denotes We are reporting a case of 2019-nCoV infection acquired outside Asia in which transmission appears to have occurred during the incubation period in the index patient.
T5 612-747 Sentence denotes A 33-year-old otherwise healthy German businessman (Patient 1) became ill with a sore throat, chills, and myalgias on January 24, 2020.
T6 748-836 Sentence denotes The following day, a fever of 39.1°C (102.4°F) developed, along with a productive cough.
T7 837-931 Sentence denotes By the evening of the next day, he started feeling better and went back to work on January 27.
T8 932-1067 Sentence denotes Before the onset of symptoms, he had attended meetings with a Chinese business partner at his company near Munich on January 20 and 21.
T9 1068-1157 Sentence denotes The business partner, a Shanghai resident, had visited Germany between January 19 and 22.
T10 1158-1493 Sentence denotes During her stay, she had been well with no signs or symptoms of infection but had become ill on her flight back to China, where she tested positive for 2019-nCoV on January 26 (index patient in Figure 1) (see Supplementary Appendix, available at NEJM.org, for details on the timeline of symptom development leading to hospitalization).
T11 1494-1552 Sentence denotes On January 27, she informed the company about her illness.
T12 1553-1719 Sentence denotes Contact tracing was started, and the above-mentioned colleague was sent to the Division of Infectious Diseases and Tropical Medicine in Munich for further assessment.
T13 1720-1762 Sentence denotes At presentation, he was afebrile and well.
T14 1763-1889 Sentence denotes He reported no previous or chronic illnesses and had no history of foreign travel within 14 days before the onset of symptoms.
T15 1890-2243 Sentence denotes Two nasopharyngeal swabs and one sputum sample were obtained and were found to be positive for 2019-nCoV on quantitative reverse-transcriptase–polymerase-chain-reaction (qRT-PCR) assay.2 Follow-up qRT-PCR assay revealed a high viral load of 108 copies per milliliter in his sputum during the following days, with the last available result on January 29.
T16 2244-2366 Sentence denotes On January 28, three additional employees at the company tested positive for 2019-nCoV (Patients 2 through 4 in Figure 1).
T17 2367-2492 Sentence denotes Of these patients, only Patient 2 had contact with the index patient; the other two patients had contact only with Patient 1.
T18 2493-2677 Sentence denotes In accordance with the health authorities, all the patients with confirmed 2019-nCoV infection were admitted to a Munich infectious diseases unit for clinical monitoring and isolation.
T19 2678-2760 Sentence denotes So far, none of the four confirmed patients show signs of severe clinical illness.
T20 2761-2848 Sentence denotes This case of 2019-nCoV infection was diagnosed in Germany and transmitted outside Asia.
T21 2849-3022 Sentence denotes However, it is notable that the infection appears to have been transmitted during the incubation period of the index patient, in whom the illness was brief and nonspecific.3
T22 3023-3179 Sentence denotes The fact that asymptomatic persons are potential sources of 2019-nCoV infection may warrant a reassessment of transmission dynamics of the current outbreak.
T23 3180-3359 Sentence denotes In this context, the detection of 2019-nCoV and a high sputum viral load in a convalescent patient (Patient 1) arouse concern about prolonged shedding of 2019-nCoV after recovery.
T24 3360-3475 Sentence denotes Yet, the viability of 2019-nCoV detected on qRT-PCR in this patient remains to be proved by means of viral culture.
T25 3476-3621 Sentence denotes Despite these concerns, all four patients who were seen in Munich have had mild cases and were hospitalized primarily for public health purposes.
T26 3622-3886 Sentence denotes Since hospital capacities are limited — in particular, given the concurrent peak of the influenza season in the northern hemisphere — research is needed to determine whether such patients can be treated with appropriate guidance and oversight outside the hospital.
T27 3888-3989 Sentence denotes Disclosure forms provided by the authors are available with the full text of this letter at NEJM.org.
T28 3991-4083 Sentence denotes This letter was published on January 30, 2020, and updated on February 6, 2020, at NEJM.org.
T29 4085-4107 Sentence denotes Supplementary Appendix
T30 4108-4144 Sentence denotes Click here for additional data file.
T31 4146-4162 Sentence denotes Disclosure Forms
T32 4163-4199 Sentence denotes Click here for additional data file.
T33 4201-4297 Sentence denotes Figure 1 Timeline of Exposure to Index Patient with Asymptomatic 2019-CoV Infection in Germany.