| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T39 |
0-63 |
Sentence |
denotes |
3 Potential antiviral effect of chloroquine against SARS-CoV-2 |
| T40 |
64-454 |
Sentence |
denotes |
Because of its broad spectrum of action against viruses, including most coronaviruses and particularly its close relative SARS-CoV-1, and because coronavirus cell entry occurs through the endolysosomal pathway [48], it made sense in a situation of a public-health emergency and the absence of any known efficient therapy to investigate the possible effect of chloroquine against SARS-CoV-2. |
| T41 |
455-650 |
Sentence |
denotes |
A recent paper reported that both chloroquine and the antiviral drug remdesivir inhibited SARS-CoV-2 in vitro and suggested these drugs be assessed in human patients suffering from COVID-19 [49]. |
| T42 |
651-855 |
Sentence |
denotes |
Recently, the China National Center for Biotechnology Development indicated that chloroquine is one of the three drugs with a promising profile against the new SARS-CoV-2 coronavirus that causes COVID-19. |
| T43 |
856-993 |
Sentence |
denotes |
Chloroquine repurposing was investigated in hospitals in Beijing, in central China's Hunan Province and South China's Guangdong Province. |
| T44 |
994-1459 |
Sentence |
denotes |
According to preliminary reports [50,51] from the Chinese authorities suggesting that approximately 100 infected patients treated with chloroquine experienced a more rapid decline in fever and improvement of lung computed tomography (CT) images and required a shorter time to recover compared with control groups, with no obvious serious adverse effects, the Chinese medical advisory board has suggested chloroquine inclusion in the SARS-CoV-2 treatment guidelines. |
| T45 |
1460-1615 |
Sentence |
denotes |
As a result, chloroquine is probably the first molecule to be used in China and abroad on the front line for the treatment of severe SARS-CoV-2 infections. |
| T46 |
1616-1950 |
Sentence |
denotes |
Although the long use of this drug in malaria therapy demonstrates the safety of acute chloroquine administration to humans, one cannot ignore the minor risk of macular retinopathy, which depends on the cumulative dose [52], and the existence of some reports on cardiomyopathy as a severe adverse effect caused by chloroquine [53,54]. |
| T47 |
1951-2059 |
Sentence |
denotes |
A survey of SARS-CoV-2-infected patients for adverse effects of chloroquine therapy remains to be performed. |
| T48 |
2060-2188 |
Sentence |
denotes |
However, chloroquine is currently among the best available candidates to impact the severity of SARS-CoV-2 infections in humans. |
| T49 |
2189-2286 |
Sentence |
denotes |
Currently, at least ten clinical trials are testing chloroquine as an anti-COVID-19 therapy [55]. |
