| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T7 |
0-126 |
Sentence |
denotes |
Infectious bronchitis (IB) is a highly infectious viral disease responsible for major economic losses in the poultry industry. |
| T8 |
127-231 |
Sentence |
denotes |
A reverse genetic vaccine is a safe, rapid, and effective method of achieving IB prevention and control. |
| T9 |
232-492 |
Sentence |
denotes |
In this study, we constructed the recombinant strain, rH120-S1/YZ, using a reverse genetic system, based on the backbone of the H120 vaccine strain, with the S1 gene replaced with that of the QX-like nephropathogenic strain, ck/CH/IBYZ/2011, isolated in China. |
| T10 |
493-676 |
Sentence |
denotes |
The results of dwarf chicken embryos, growth kinetics, and viral titration in the embryos demonstrated that the biological characteristics of the recombinant virus remained unchanged. |
| T11 |
677-877 |
Sentence |
denotes |
Like the rH120-infected group and in contrast to the rIBYZ-infected group, no mortality, clinical signs, or lesions were observed in the lungs or kidneys of young chickens inoculated with rH120-S1/YZ. |
| T12 |
878-1039 |
Sentence |
denotes |
The viral loads in various tissues, cloacal, and oral swabs was lower in most types of samples, indicating that the rH120-S1/YZ strain was highly safe in chicks. |
| T13 |
1040-1295 |
Sentence |
denotes |
Compared to rH120 vaccination group, when the efficacy of this strain was evaluated against the QX-like IBV strain, better protection, with 100% survival rate and no disease symptom or gross lesion was observed in the chickens vaccinated with rH120-S1/YZ. |
| T14 |
1296-1430 |
Sentence |
denotes |
Increased levels of IBV-specific antibodies were detected in the serum of the rH120-S1/YZ-vaccinated animals 14 days post-vaccination. |
| T15 |
1431-1572 |
Sentence |
denotes |
Collectively, our results suggest that the recombinant strain, rH120-S1/YZ, may represent a promising vaccine candidate against QX-like IBVs. |
