| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T255 |
0-252 |
Sentence |
denotes |
In addition to its role in tissue tropism, the S1 glycoprotein also has an important function in inducing a neutralizing antibody response [64], [65], and small differences in the S1 contribute to poor cross protectionby neutralization test [64], [66]. |
| T256 |
253-463 |
Sentence |
denotes |
To evaluate the protective efficacy of this candidate vaccine, we selected the QX-like virulent rIBYZ strain to infect chickens at 14 dpv that were vaccinated with either the rH120-S1/YZ strain or rH120 strain. |
| T257 |
464-652 |
Sentence |
denotes |
We found that little protection against rIBYZ virulent strain challenge in the rH120 vaccinated group was induced, with a 50% survival rate and severe clinical symptoms associated with IB. |
| T258 |
653-744 |
Sentence |
denotes |
This finding could be explained by differences in the antigenicity between rH120 and rIBYZ. |
| T259 |
745-938 |
Sentence |
denotes |
No death, clinical signs, or lesions were observed in the rH120-S1/YZ-vaccinated group, indicating that this strain could provide effective protection against rIBYZ challenge in young chickens. |
| T260 |
939-1189 |
Sentence |
denotes |
Since high humoral antibody titers can contribute to reduced viral replication in various organs and disease recovery [67], [68], the level of specific IgG antibodies remains an important standard for evaluating the immune response to an IBV vaccine. |
| T261 |
1190-1362 |
Sentence |
denotes |
In the present study, the humoral antibody level of chickens vaccinated with the rH120-S1/YZ strain was observed to gradually increase compared to the non-vaccinated group. |
| T262 |
1363-1703 |
Sentence |
denotes |
However, although the rH120 strain was able to induce similar levels of humoral antibodies, it provided poor protection against rIBYZ, suggesting that protection against IBV infection is not only with humoral immunity, but also with both mucosal immunity combined with the local tracheal and cellular immune response [69], [70], [71], [72]. |
| T263 |
1704-1820 |
Sentence |
denotes |
Thus, the detection of mucosal and cellular immunity in rH120-S1/YZ-vaccinated animals requires further exploration. |
| T264 |
1821-2074 |
Sentence |
denotes |
Nevertheless, some studies have shown that a peptide located near the amino terminal end of S2 can be recognized by neutralizing monoclonal antibodies [73], and the S2 domain also plays an important role in inducing protective immunity [28], [61], [74]. |
| T265 |
2075-2371 |
Sentence |
denotes |
Because the S2 domain plays an important role in cell tropism [57], we also considered that expressing the S1 subunit would provide greater safety than the entire S gene, which could lead to further destruction in some organs of the vaccinated chickens; however, further experiments are required. |
