PMC:7113610 / 21418-24588 JSONTXT 13 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T157 0-26 Sentence denotes Conclusion and perspective
T158 27-220 Sentence denotes The novel coronavirus originated from the Hunan seafood market at Wuhan, China where bats, snakes, raccoon dogs, palm civets, and other animals are sold, and rapidly spread up to 109 countries.
T159 221-342 Sentence denotes The zoonotic source of SARS-CoV-2 is not confirmed, however, sequence-based analysis suggested bats as the key reservoir.
T160 343-564 Sentence denotes DNA recombination was found to be involved at spike glycoprotein which assorted SARS-CoV (CoVZXC21 or CoVZC45) with the RBD of another Beta CoV, thus could be the reason for cross-species transmission and rapid infection.
T161 565-639 Sentence denotes According to phylogenetic trees, SARS-CoV is closer to SARS-like bat CoVs.
T162 640-757 Sentence denotes Until now, no promising clinical treatments or prevention strategies have been developed against human coronaviruses.
T163 758-876 Sentence denotes However, the researchers are working to develop efficient therapeutic strategies to cope with the novel coronaviruses.
T164 877-1089 Sentence denotes Various broad-spectrum antivirals previously used against influenza, SARS and MERS coronaviruses have been evaluated either alone or in combinations to treat COVID-19 patients, mice models, and clinical isolates.
T165 1090-1206 Sentence denotes Remdesivir, Lopinavir, Ritonavir, and Oseltamivir significantly blocked the COVID-19 infection in infected patients.
T166 1207-1343 Sentence denotes It can be cocluded that the homologus recombination event at the S protein of RBD region enhanced the transmission ability of the virus.
T167 1344-1529 Sentence denotes While the decision of bring back the nationals from infected area by various countries and poor screening of passengers, become the leading cause of spreading virus in others countries.
T168 1530-1693 Sentence denotes Most importantly, human coronaviruses targeting vaccines and antiviral drugs should be designed that could be used against the current as well as future epidemics.
T169 1694-1988 Sentence denotes There are many companies working for the development of effective SARS-CoV-2 vaccines, such as Moderna Therapeutics, Inovio Pharmaceuticals, Novavax, Vir Biotechnology, Stermirna Therapeutics, Johnson & Johnson, VIDO-InterVac, GeoVax-BravoVax, Clover Biopharmaceuticals, CureVac, and Codagenix.
T170 1989-2115 Sentence denotes But there is a need for rapid human and animal-based trails as these vaccines still require 3–10 months for commercialization.
T171 2116-2201 Sentence denotes There must be a complete ban on utilizing wild animals and birds as a source of food.
T172 2202-2329 Sentence denotes Beside the development of most efficient drug, a strategy to rapidly diagnose SARS-CoV-2 in suspected patient is also required.
T173 2330-2457 Sentence denotes The signs and symptoms of SARS-CoV-2 induced COVID-19 are a bit similar to influenza and seasonal allergies (pollen allergies).
T174 2458-2619 Sentence denotes Person suffering from influenza or seasonal allergy may also exhibit temprature which can be detected by thermo-scanners, hence the person will become suspected.
T175 2620-2797 Sentence denotes Therefore, an accurate and rapid diagnostic kit or meter for detection of SARS-CoV-2 in suspected patients is required, as the PCR based testing is expensive and time consuming.
T176 2798-3082 Sentence denotes Different teams of Chinese doctors should immediately sent to Eurpean and other countries, especially spain and Italy to control the over spread of COVID-19, because Chinese doctors have efficiently controlled the outbreak in china and limited the mortality rate to less than 3% only.
T177 3083-3170 Sentence denotes The therapeutic strategies used by Chinese, should also be followed by other countries.