| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T280 |
0-62 |
Sentence |
denotes |
MERS-CoV Subunit Vaccines Based on Non-RBD S Protein Fragments |
| T281 |
63-170 |
Sentence |
denotes |
MERS vaccines targeting non-RBD regions of S protein have been developed and investigated in mice and NHPs. |
| T282 |
171-467 |
Sentence |
denotes |
It has been shown that a MERS-CoV S1 protein formulated with Ribi (for mice) or aluminum phosphate (for NHPs) adjuvant elicited robust neutralizing antibodies in mice and NHPs against divergent strains of pseudotyped and live MERS-CoV, protecting NHPs from MERS-CoV infection (Wang et al., 2015). |
| T283 |
468-927 |
Sentence |
denotes |
In addition, MERS-CoV S1 protein adjuvanted with Advax and Sigma Adjuvant System induced low-titer neutralizing antibodies in dromedary camels with reduced and delayed viral shedding after MERS-CoV challenge, but high-titer neutralizing antibodies in alpacas with complete protection of viral shedding from viral infection, indicating that protection of MERS-CoV infection is positively correlated with serum neutralizing antibody titers (Adney et al., 2019). |
| T284 |
928-1148 |
Sentence |
denotes |
Moreover, immunization with a recombinant MERS-CoV NTD protein (rNTD) can induce neutralizing antibodies and cell-mediated responses, protecting Ad-hDPP4-transduced mice against MERS-CoV challenge (Jiaming et al., 2017). |
| T285 |
1149-1376 |
Sentence |
denotes |
Notably, specific antibodies with neutralizing activity have been elicited by a S2 peptide sequence (residues 736–761) of MERS-CoV in rabbits (Yang et al., 2014a), but the protective efficacy of this peptide vaccine is unknown. |
| T286 |
1377-1519 |
Sentence |
denotes |
The above reports demonstrate the potential for the development of MERS subunit vaccines based on the non-RBD fragments of MERS-CoV S protein. |
