| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T211 |
0-60 |
Sentence |
denotes |
SARS-CoV Subunit Vaccines Based on Non-S Structural Proteins |
| T212 |
61-207 |
Sentence |
denotes |
Subunit vaccines based on the N and M proteins of SARS-CoV have shown immunogenicity in vaccinated animals (Liu et al., 2006; Zheng et al., 2009). |
| T213 |
208-652 |
Sentence |
denotes |
Studies have revealed that a plant-expressed SARS-CoV N protein conjugated with Freund’s adjuvant elicited specific IgG antibodies, including IgG1 and IgG2a subtypes, and cellular immune responses in mice, whereas another E. coli-expressed N protein conjugated with Montanide ISA-51 and cysteine-phosphate-guanine (CpG) adjuvants induced specific IgG antibodies toward a Th1 (IgG2a)-type response in mice (Liu et al., 2006; Zheng et al., 2009). |
| T214 |
653-846 |
Sentence |
denotes |
Although N-specific antibodies have been detected in convalescent-phase SARS patient and immunized rabbit sera, they have no neutralizing activity against SARS-CoV infection (Qiu et al., 2005). |
| T215 |
847-1093 |
Sentence |
denotes |
In addition, immunodominant M protein peptides (M1-31 and M132-161) identified using convalescent-phase sera of SARS patients and immunized mouse and rabbit sera have immunogenicity to elicit specific IgG antibodies in rabbits (He et al., 2005b). |
| T216 |
1094-1271 |
Sentence |
denotes |
In spite of their immunogenicity, it appears that these N- and M-based SARS subunit vaccines have not been investigated for their protective efficacy against SARS-CoV infection. |
| T217 |
1272-1390 |
Sentence |
denotes |
Thus, it is unclear whether these non-S structural protein-based SARS subunit vaccines can prevent SARS-CoV infection. |
