| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T158 |
0-137 |
Sentence |
denotes |
Name Antigenicity and functionality Adjuvant Route Animal models Antibody response Cellular immune response Protection References |
| T159 |
138-206 |
Sentence |
denotes |
Subunit vaccines based on SARS-CoV full-length or trimeric S protein |
| T160 |
207-299 |
Sentence |
denotes |
FL-S and EC-S proteins Bind to SARS-CoV S1, NTD, RBD, and S2-specific mAbs MPL + TDM S.C. |
| T161 |
301-355 |
Sentence |
denotes |
BALB/c mice Elicit SARS-CoV S-specific Abs (IgG, > 1: |
| T162 |
356-473 |
Sentence |
denotes |
2 × 105), neutralizing (> 1:2.4 × 104) pseudotyped SARS-CoV (Tor2, GD03, and SZ3 strains) N/A N/A He et al., 2006a |
| T163 |
474-546 |
Sentence |
denotes |
S andS-foldon proteins N/A TiterMax Gold; Alum Hydro+MPL S.C. or I.M. |
| T164 |
548-842 |
Sentence |
denotes |
BALB/c mice Elicit SARS-CoV S-specific Abs (IgG, > 1:104) in mice, neutralizing (∼2.4 × 102 for S; ∼1:7 × 102 for S-foldon) live SARS-CoV (Urbani strain) N/A Protect vaccinated mice from challenge of SARS-CoV (Urbani strain, 105 TCID50) with undetectable viral load in lungs Li et al., 2013 |
| T165 |
843-890 |
Sentence |
denotes |
triSpike protein N/A Alum hydro I.P. or S.C. |
| T166 |
892-1273 |
Sentence |
denotes |
BALB/c mice; Hamsters Elicits SARS-CoV S-specific mucosal and serum Abs (IgA and IgG) in mice and hamsters, blocking S-ACE2 receptor binding and neutralizing live SARS-CoV (HKU-39849 strain); induces ADE N/A Protects vaccinated hamsters from challenge of SARS-CoV (Urbani strain, 103 TCID50) with undetectable or reduced viral load in lungs Kam et al., 2007; Jaume et al., 2012 |
| T167 |
1274-1320 |
Sentence |
denotes |
Subunit vaccines based on SARS-CoV RBD protein |
| T168 |
1321-1364 |
Sentence |
denotes |
RBD-Fc protein N/A Freund’s I.D. or I.M. |
| T169 |
1366-1514 |
Sentence |
denotes |
BALB/c mice; Rabbits Elicits SARS-CoV S/RBD-specific Abs (IgG) in mice and rabbits, neutralizing pseudotyped (rabbits: ≥ 7.3 × 104) and live (mice: |
| T170 |
1515-1762 |
Sentence |
denotes |
1:4 × 103; rabbits: > 1:1.5 × 104) SARS-CoV (BJ01 strain) N/A Protects majority (4/5) of vaccinated mice from challenge of SARS-CoV (BJ01 strain, 106 TCID50), with one mouse showing mild alveolar damage in lungs He et al., 2004; Du et al., 2007 |
| T171 |
1763-1915 |
Sentence |
denotes |
RBD193-CHO; RBD219-CHO proteins Binds to SARS-CoV RBD-specific mAbs (neutralizing 24H8, 31H12, 35B5, 33G4, 19B2; non-neutralizing 17H9) Freund’s S.C. |
| T172 |
1917-2484 |
Sentence |
denotes |
BALB/c mice Elicit SARS-CoV RBD-specific Abs, neutralizing pseudotyped (< 1:104 for RBD193-CHO; 1:5.8 × 104 for RBD219-CHO) and live (< 1:103 for RBD193-CHO; 1:103 for RBD219-CHO) SARS-CoV (GZ50 strain) Induce SARS-CoV RBD-specific cellular immune responses (IFN-γ, IL-2, IL-4, IL-10) in mice Protect all (for RBD219-CHO) or majority (3/5, for RBD219-CHO) of vaccinated mice from challenge of SARS-CoV (GZ50 strain, 100 TCID50 for RBD193-CHO; 5 × 105 TCID50 for RBD219-CHO) with undetectable viral RNA or no, to reduced, viral load in lungs Du et al., 2009c, 2010 |
| T173 |
2485-2617 |
Sentence |
denotes |
RBD-293T protein Binds to SARS-CoV RBD-specific mAbs (neutralizing 24H8, 31H12, 35B5, 33G4, 19B2; non-neutralizing 17H9) SAS S.C. |
| T174 |
2619-2915 |
Sentence |
denotes |
BALB/c mice Elicits SARS-CoV RBD-specific Abs (IgG), neutralizing pseudotyped (1:6.9 × 105) and live (1:1.6 × 103) SARS-CoV (GZ50 strain) N/A Protects all vaccinated mice from challenge of SARS-CoV (GZ50 strain, 100 TCID50) with undetectable viral RNA and viral load in lungs Du et al., 2009b |
| T175 |
2916-2961 |
Sentence |
denotes |
S318-510 protein N/A Alum; Alum + CpG S.C. |
| T176 |
2963-3041 |
Sentence |
denotes |
129S6/SvEv mice Elicits SARS-CoV-specific Abs (IgG, IgG1, and IgG2a) in mice. |
| T177 |
3042-3196 |
Sentence |
denotes |
Reduces neutralization after removing glycosylation Induces SARS-CoV S-specific cellular immune responses (IFN-γ) in mice N/A Zakhartchouk et al., 2007 |
| T178 |
3197-3259 |
Sentence |
denotes |
Subunit vaccines based on non-RBD SARS-CoV S protein fragments |
| T179 |
3260-3337 |
Sentence |
denotes |
S1 and S1-foldon proteins N/A TiterMax Gold; Alum Hydro + MPL S.C. or I.M. |
| T180 |
3339-3630 |
Sentence |
denotes |
BALB/c mice Elicit SARS-CoV S-specific Abs (IgG, > 1:104) in mice, neutralizing (1:1.7 × 102 for S1; 1:90 for S1-foldon) live SARS-CoV (Urbani strain) N/A Protect vaccinated mice from challenge of SARS-CoV (Urbani strain, 105 TCID50) with undetectable viral load in lungs Li et al., 2013 |
| T181 |
3631-3662 |
Sentence |
denotes |
S2 protein N/A Freund’s S.C. |
| T182 |
3664-3870 |
Sentence |
denotes |
BALB/c mice Elicits SARS-CoV S2-specific Abs (IgG, 1:1.6 × 103) in mice with no neutralizing activity Induces SARS-CoV S2-specific cellular immune responses (IFN-γ and IL-4) in mice N/A Guo et al., 2005 |
| T183 |
3871-3946 |
Sentence |
denotes |
Subunit vaccines based on SARS-CoV non-S structural proteins (i.e. N and M) |
| T184 |
3947-3978 |
Sentence |
denotes |
rN protein N/A Freund’s I.P. |
| T185 |
3980-4181 |
Sentence |
denotes |
BALB/c mice Elicits SARS-CoV N-specific Abs (IgG (1:1.8 × 103), IgG1, and IgG2a) in mice Induces cellular immune responses with up-regulated IFN-γ and IL-10 cytokines in mice N/A Zheng et al., 2009 |
| T186 |
4182-4230 |
Sentence |
denotes |
rN protein N/A Montanide + CpG; Freund’s S.C. |
| T187 |
4232-4385 |
Sentence |
denotes |
BALB/c mice Elicits SARS-CoV N-specific Abs (IgG) in mice Induces SARS-CoV N-specific cellular immune responses (IFN- γ) in mice N/A Liu et al., 2006 |
| T188 |
4386-4492 |
Sentence |
denotes |
M1-31 and M132-161 peptides Bind to sera from SARS patients or immunized mice and rabbits Freund’s I.D. |
| T189 |
4494-4595 |
Sentence |
denotes |
BALB/c mice; NZW rabbits Induce SARS-CoV M-specific Abs (IgG) in rabbits N/A N/A He et al., 2005b |
