LitCovid-sentences  

PMC:7105881 / 13012-15177 JSONTXT 13 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T77 0-85 Sentence denotes Several proteins of human CoVs are important for viral infection and/or pathogenesis.
T78 86-190 Sentence denotes For example, most nsps participate in viral RNA replication and/or transcription (Snijder et al., 2016).
T79 191-353 Sentence denotes The accessory proteins interact with host cells, potentially helping the viruses to evade the immune system and increase their virulence (Menachery et al., 2017).
T80 354-534 Sentence denotes The HE protein assists in the attachment of virus–host cells, thus playing a key role in the production of infectious virions, as in the case of HCoV-OC43 (Desforges et al., 2013).
T81 535-656 Sentence denotes The M and E proteins are responsible for virus assembly or promote virulence (Scobey et al., 2013; DeDiego et al., 2014).
T82 657-850 Sentence denotes Different from the above proteins, the S protein of human CoVs mediates viral entry into host cells and subsequent membrane fusion, enabling viral infection (Du et al., 2009a; Lu et al., 2014).
T83 851-1008 Sentence denotes The S protein is a class I viral protein, which can be cleaved into two functional subunits, an amino-terminal S1 subunit and a carboxyl-terminal S2 subunit.
T84 1009-1178 Sentence denotes The S1 subunit is responsible for virus–host cell receptor binding, whereas the S2 subunit is involved in virus–host membrane fusion (Li et al., 2005a; Lu et al., 2014).
T85 1179-1271 Sentence denotes The S1 contains two major domains, an N-terminal domain (NTD) and a C-terminal domain (CTD).
T86 1272-1515 Sentence denotes In general, NTDs mediate sugar binding (Li, 2016; Li et al., 2017; Ou et al., 2017; Hulswit et al., 2019; Tortorici et al., 2019), whereas CTDs facilitate protein receptor recognition (Wong et al., 2004; Hofmann et al., 2006; Lu et al., 2013).
T87 1516-1663 Sentence denotes The NTDs and CTDs of the S1 subunit can bind host receptors or function as receptor-binding domains (RBDs) (Lu et al., 2013; Hulswit et al., 2019).
T88 1664-1759 Sentence denotes The entry of human CoVs relies on the interaction between viral and cellular membrane proteins.
T89 1760-1870 Sentence denotes Recognition of S1 subunit with a receptor and/or sugar on the cell surface initiates the infection (Li, 2015).
T90 1871-2046 Sentence denotes After the initial recognition and binding, the S protein undergoes conformational changes, followed by membrane fusion through the S2 region (Li, 2015, 2016; Du et al., 2017).
T91 2047-2165 Sentence denotes Consequently, the viral genetic materials are delivered into the host cell through the fusion core (Du et al., 2009a).