PMC:7103735 / 44827-45706 JSON TXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE

Id	Subject	Object	Predicate	Lexical cue
T368	0-9	Sentence	denotes	Figure 2.
T369	10-70	Sentence	denotes	A working model of SARS-CoV-induced inflammasome activation.
T370	71-143	Sentence	denotes	SARS-CoV can activate both signal 1 (priming) and signal 2 (activation).
T371	144-216	Sentence	denotes	Upregulation of pro-IL-1β transcription is achieved by NF-κB activation.
T372	217-271	Sentence	denotes	Two mechanisms of IL-1β maturation have been proposed.
T373	272-389	Sentence	denotes	In the first model, potassium ion efflux is promoted by ORF3a and E proteins, leading to NLRP3 inflammasome assembly.
T374	390-479	Sentence	denotes	Alternatively, ORF3a promotes ASC ubiquitination and consequent assembly of inflammasome.
T375	480-521	Sentence	denotes	ORG8b interacts with and activates NLRP3.
T376	522-610	Sentence	denotes	Activation of inflammasome leads to proteolytic cleavage of pro-caspase 1 and pro-IL-1β.
T377	611-674	Sentence	denotes	ASC, apoptosis-associated speck-like protein containing a CARD.
T378	675-692	Sentence	denotes	CASP1, caspase 1.
T379	693-709	Sentence	denotes	IKK, IκB kinase.
T380	710-730	Sentence	denotes	IL-1, interleukin-1.
T381	731-756	Sentence	denotes	LPS, lipopolysaccharides.
T382	757-813	Sentence	denotes	NLRP3, NACHT, LRR, and PYD domains-containing protein 3.
T383	814-846	Sentence	denotes	NEMO, NF-κB essential modulator.
T384	847-879	Sentence	denotes	TNF-α, tumour necrosis factor α.