LitCovid-sentences  

PMC:7103696 / 9146-12838 JSONTXT 14 Projects

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Id Subject Object Predicate Lexical cue
T77 0-102 Sentence denotes Professor Wenhong Zhang (responsible for Shanghai’s overall clinical management of the COVID-19 cases)
T78 103-401 Sentence denotes Since late January, I have been working to ensure the high-quality care of COVID-19 patient by building a highly experienced clinician team, Shanghai Clinical Treatment Expert Group, based on group members’ clinical and scientific expertise to provide the advice to complicated clinical management.
T79 403-446 Sentence denotes A team approach to manage COVID-19 patients
T80 447-549 Sentence denotes Currently, there have been more than 330 laboratory-confirmed adult cases of COVID-19 in Shanghai [7].
T81 550-667 Sentence denotes Most patients (>90%) are in mild or moderate states, and more than 90% of them have been cured and discharged by now.
T82 668-1005 Sentence denotes Because no specific drugs have been shown with clear effectiveness in helping the human body to clear the SARS-CoV-2 viruses, the disease severity rate in Shanghai (26 cases, around 9–10%) actually objectively reflected the natural history of the disease, and was comparable with the severity rate at other places outside Hubei Province.
T83 1006-1145 Sentence denotes All critically ill patients received invasive mechanical ventilation, and six patients received extracorporeal membrane oxygenation (ECMO).
T84 1146-1373 Sentence denotes We found that in addition to the involvement of the respiratory system, critically ill patients often had systemic involvement of multiple organs, including the heart, kidney, and coagulation system in the early disease course.
T85 1374-1472 Sentence denotes Sometimes multiple system involvement was observed even at the time of initial hospital admission.
T86 1473-1596 Sentence denotes Therefore, in addition to the respiratory supportive treatment, timely multiorgan evaluation and treatment is very crucial.
T87 1597-1829 Sentence denotes Every critically ill COVID-19 patient in Shanghai is managed by a group of healthcare providers which includes at least a pulmonologist, an infectious diseases expert, a critical care specialist, and an ECMO specialist if necessary.
T88 1830-1984 Sentence denotes Nephrologists, psychiatrists, physicians of traditional Chinese medicine, experienced nurses also actively participate in managing these patients as well.
T89 1985-2052 Sentence denotes Besides, substantial heterogeneity among severe patients was noted.
T90 2053-2133 Sentence denotes Mild patients are more alike, but each severe case is severe in his/her own way.
T91 2134-2219 Sentence denotes There may be multiple pathophysiological mechanisms in these critically ill patients.
T92 2220-2431 Sentence denotes The types of critically ill patients need to be more carefully classified in order to perform more individualized treatment, in addition to conducting more dedicated research to develop a unique management plan.
T93 2432-2557 Sentence denotes In Shanghai, medical decisions and interventions are carefully tailored to the unique characteristics of each severe patient.
T94 2559-2614 Sentence denotes Early and effective treatment of mild cases is critical
T95 2615-2668 Sentence denotes The overall mortality rate is about 0.9% in Shanghai.
T96 2669-2861 Sentence denotes However, we have found that once the disease course progressed to the critical illness state (requiring mechanical ventilation), the prognosis of the patients would become significantly worse.
T97 2862-3046 Sentence denotes From this perspective, treatments that can prevent mild state from progressing to the severe or critical state will significantly improve the overall prognosis of the clinical courses.
T98 3047-3200 Sentence denotes Such effective treatments include intermittent short-term haemofiltration (ISVVH), low-dose short-course glucocorticoids therapy, among other approaches.
T99 3201-3293 Sentence denotes The use of glucocorticoids is rather controversial and there is no general agreement by now.
T100 3294-3470 Sentence denotes Based on our experiences, stably mild patients could self-manage the infection effectively and corticosteroid would not be recommended for them considering its potential risks.
T101 3471-3623 Sentence denotes For patients who have an overly exuberant inflammatory response or are at high risk of developing ARDS, early-start of corticosteroids could be helpful.
T102 3624-3692 Sentence denotes The benefit of corticosteroids as rescue treatment remains doubtful.