LitCovid-sentences  

PMC:7102662 / 6321-8729 JSONTXT 13 Projects

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Id Subject Object Predicate Lexical cue
T57 0-63 Sentence denotes SARS-CoV-2 is caused by a novel enveloped RNA beta-coronavirus.
T58 64-293 Sentence denotes Seven species of these beta-coronaviruses are known to cause human infections, with four mainly causing mild flulike symptoms and the remaining three resulting in potentially fatal illnesses (SARS, MERS and the ongoing COVID-19).
T59 294-412 Sentence denotes Although respiratory tract is the primary target for SARS-CoV-2, CV system may get involved in several different ways.
T60 413-502 Sentence denotes Following are the common mechanisms responsible for CV complications in COVID-19 [3,4]-1.
T61 504-691 Sentence denotes Direct myocardial injury- SARS-CoV-2 enters human cells by binding to angiotensin-converting enzyme 2 (ACE2), a membrane bound aminopeptidase which is highly expressed in heart and lungs.
T62 692-819 Sentence denotes ACE2 plays an important role in neurohumoral regulation of CV system in normal health as well as in various disease conditions.
T63 820-957 Sentence denotes The binding of SARS-CoV-2 to ACE2 can result in alteration of ACE2 signaling pathways, leading to acute myocardial and lung injury [3,4].
T64 958-960 Sentence denotes 2.
T65 962-1169 Sentence denotes Systemic inflammation- More severe forms of COVID-19 are characterized by acute systemic inflammatory response and cytokine storm, which can result in injury to multiple organs leading to multiorgan failure.
T66 1170-1290 Sentence denotes Studies have shown high circulatory levels of proinflammatory cytokines in patients with severe/critical COVID-19 [5,6].
T67 1291-1293 Sentence denotes 3.
T68 1295-1556 Sentence denotes Altered myocardial demand-supply ratio- Increased cardiometabolic demand associated with the systemic infection coupled with hypoxia caused by acute respiratory illness can impair myocardial oxygen demand-supply relationship and lead to acute myocardial injury.
T69 1557-1559 Sentence denotes 4.
T70 1561-1766 Sentence denotes Plaque rupture and coronary thrombosis- Systemic inflammation as well as increased shear stress due to increased coronary blood flow can precipitate plaque rupture resulting in acute myocardial infarction.
T71 1767-1848 Sentence denotes Prothrombotic milieu created by systemic inflammation further increases the risk.
T72 1849-1851 Sentence denotes 5.
T73 1853-2030 Sentence denotes Adverse effects of various therapies- Various antiviral drugs, corticosteroids and other therapies aimed at treating COVID-19 can also have deleterious effects on the CV system.
T74 2031-2033 Sentence denotes 6.
T75 2035-2204 Sentence denotes Electrolyte imbalances- Electrolyte imbalances can occur in any critical systemic illness and precipitate arrhythmias, esp. in patients with underlying cardiac disorder.
T76 2205-2343 Sentence denotes There is particular concern about hypokalemia in COVID-19, due to interaction of SARS-CoV-2 with renin-angiotensin-aldosterone system [7].
T77 2344-2408 Sentence denotes Hypokalemia increases vulnerability to various tachyarrhythmias.