PMC:7102662 / 2121-4809 JSONTXT 14 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T24 0-205 Sentence denotes The emergence of novel coronavirus, officially known as Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2), has presented an unprecedented challenge for the healthcare community across the world.
T25 206-410 Sentence denotes High infectivity, ability to get transmitted even during asymptomatic phase and relatively low virulence have resulted in rapid transmission of this virus beyond geographic regions, leading to a pandemic.
T26 411-555 Sentence denotes The first case of this disease, known as coronavirus disease 2019 (COVID-2019), occurred on December 8, 2019 in the Hubei province of China [1].
T27 556-798 Sentence denotes Since then, within a short span of just over 3 months, the infection has spread to 177 countries/area/territories across the world, with 266073 confirmed cases and 11184 deaths (World Health Organization statistics as on March 21, 2020) [2] .
T28 799-864 Sentence denotes Table 1 Cardiovascular complications in coronavirus disease 2019.
T29 865-896 Sentence denotes Manifestation Incidence Remarks
T30 897-1095 Sentence denotes Acute cardiac injury∗ (most commonly defined as elevation of cardiac troponin I above 99th percentile upper reference limit) 8–12% on average [10] • Most commonly reported cardiovascular abnormality
T31 1096-1171 Sentence denotes • Can result from any of the following mechanisms-•Direct myocardial injury
T32 1172-1194 Sentence denotes •Systemic inflammation
T33 1195-1236 Sentence denotes •Myocardial oxygen demand supply mismatch
T34 1237-1258 Sentence denotes •Acute coronary event
T35 1259-1270 Sentence denotes •Iatrogenic
T36 1271-1304 Sentence denotes • Strong adverse prognostic value
T37 1305-1442 Sentence denotes Acute coronary event Not reported, but appears to be low Potential mechanisms-• Plaque rupture due to inflammation/increased shear stress
T38 1443-1496 Sentence denotes • Aggravation of pre-existing coronary artery disease
T39 1497-1663 Sentence denotes Left ventricular systolic dysfunction Not reported Any of the causes of myocardial dysfunction mentioned above can lead to acute left ventricular systolic dysfunction
T40 1664-1868 Sentence denotes Heart failure Reported in one study- 52% in those who died, 12% in those who recovered and were discharged [5] • Any of the causes of myocardial dysfunction mentioned above can lead to acute heart failure
T41 1869-1987 Sentence denotes • Increased metabolic demand of a systemic disease can cause acute decompensation of pre-existing stable heart failure
T42 1988-2142 Sentence denotes Arrhythmia 16.7% overall; 44.4 in severe illness, 8.9% in mild cases [8] Both tachyarrhythmia and bradyarrhythmia can occur but exact nature not described
T43 2143-2248 Sentence denotes Potential long-term consequences Too early to assess Too early to ascertain for coronavirus disease 2019.
T44 2249-2457 Sentence denotes However, patients recovering from a similar earlier illness- Severe Acute Respiratory Syndrome- continued to have long-term abnormalities of lipid and glucose metabolism and of cardiovascular homeostasis [12]
T45 2458-2688 Sentence denotes ∗ Acute cardiac injury is a non-specific term with significant overlap with other cardiovascular manifestations; however, it is listed here because of how reporting has been done in most of the studies on coronavirus disease 2019.