LitCovid-sentences  

PMC:7102662 / 2105-5784 JSONTXT 14 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T23 0-15 Sentence denotes 1 Introduction
T24 16-221 Sentence denotes The emergence of novel coronavirus, officially known as Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2), has presented an unprecedented challenge for the healthcare community across the world.
T25 222-426 Sentence denotes High infectivity, ability to get transmitted even during asymptomatic phase and relatively low virulence have resulted in rapid transmission of this virus beyond geographic regions, leading to a pandemic.
T26 427-571 Sentence denotes The first case of this disease, known as coronavirus disease 2019 (COVID-2019), occurred on December 8, 2019 in the Hubei province of China [1].
T27 572-814 Sentence denotes Since then, within a short span of just over 3 months, the infection has spread to 177 countries/area/territories across the world, with 266073 confirmed cases and 11184 deaths (World Health Organization statistics as on March 21, 2020) [2] .
T28 815-880 Sentence denotes Table 1 Cardiovascular complications in coronavirus disease 2019.
T29 881-912 Sentence denotes Manifestation Incidence Remarks
T30 913-1111 Sentence denotes Acute cardiac injury∗ (most commonly defined as elevation of cardiac troponin I above 99th percentile upper reference limit) 8–12% on average [10] • Most commonly reported cardiovascular abnormality
T31 1112-1187 Sentence denotes • Can result from any of the following mechanisms-•Direct myocardial injury
T32 1188-1210 Sentence denotes •Systemic inflammation
T33 1211-1252 Sentence denotes •Myocardial oxygen demand supply mismatch
T34 1253-1274 Sentence denotes •Acute coronary event
T35 1275-1286 Sentence denotes •Iatrogenic
T36 1287-1320 Sentence denotes • Strong adverse prognostic value
T37 1321-1458 Sentence denotes Acute coronary event Not reported, but appears to be low Potential mechanisms-• Plaque rupture due to inflammation/increased shear stress
T38 1459-1512 Sentence denotes • Aggravation of pre-existing coronary artery disease
T39 1513-1679 Sentence denotes Left ventricular systolic dysfunction Not reported Any of the causes of myocardial dysfunction mentioned above can lead to acute left ventricular systolic dysfunction
T40 1680-1884 Sentence denotes Heart failure Reported in one study- 52% in those who died, 12% in those who recovered and were discharged [5] • Any of the causes of myocardial dysfunction mentioned above can lead to acute heart failure
T41 1885-2003 Sentence denotes • Increased metabolic demand of a systemic disease can cause acute decompensation of pre-existing stable heart failure
T42 2004-2158 Sentence denotes Arrhythmia 16.7% overall; 44.4 in severe illness, 8.9% in mild cases [8] Both tachyarrhythmia and bradyarrhythmia can occur but exact nature not described
T43 2159-2264 Sentence denotes Potential long-term consequences Too early to assess Too early to ascertain for coronavirus disease 2019.
T44 2265-2473 Sentence denotes However, patients recovering from a similar earlier illness- Severe Acute Respiratory Syndrome- continued to have long-term abnormalities of lipid and glucose metabolism and of cardiovascular homeostasis [12]
T45 2474-2704 Sentence denotes ∗ Acute cardiac injury is a non-specific term with significant overlap with other cardiovascular manifestations; however, it is listed here because of how reporting has been done in most of the studies on coronavirus disease 2019.
T46 2705-2898 Sentence denotes Respiratory involvement, presenting as mild flulike illness to potentially lethal acute respiratory distress syndrome or fulminant pneumonia, is the dominant clinical manifestation of COVID-19.
T47 2899-3053 Sentence denotes However, much like any other respiratory tract infection, pre-existing cardiovascular disease (CVD) and CV risk factors enhance vulnerability to COVID-19.
T48 3054-3149 Sentence denotes Further, COVID-19 can worsen underlying CVD and even precipitate de novo cardiac complications.
T49 3150-3259 Sentence denotes This review is aimed at providing overview of various CV manifestations in patients presenting with COVID-19.
T50 3260-3384 Sentence denotes The impact of pre-existing CVD and new onset cardiac complications on clinical outcomes in these patients is also discussed.
T51 3385-3679 Sentence denotes Since our understanding on this subject is only evolving at this stage, the information contained in the subsequent text is based mainly on the limited early experience with COVID-19 and learnings from the previous coronavirus illnesses, namely SARS and Middle-East Respiratory Syndrome (MERS).