LitCovid-sentences  

PMC:7102662 / 14765-18861 JSONTXT 12 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T122 0-181 Sentence denotes The overall management principles for patients presenting with COVID-19 who develop CV complications or who have pre-existing CVD are same as for any other patient without COVID-19.
T123 182-250 Sentence denotes However, there are a few important points that need consideration-1.
T124 251-371 Sentence denotes As caregivers, it is our utmost responsibility to protect ourselves from getting infected while managing these patients.
T125 372-496 Sentence denotes Therefore, all heathcare personnel engaged in the care of COVID-19 patients must observe necessary precautions at all times.
T126 497-647 Sentence denotes All of them should be trained in donning, usage, and doffing of the personal protective equipment in accordance with the existing practice guidelines.
T127 648-650 Sentence denotes 2.
T128 651-811 Sentence denotes The hospital systems need to ensure preparedness for dealing with large volume of COVID-19 patients, many of whom would need ICU care and/or acute cardiac care.
T129 812-971 Sentence denotes Appropriate protocols for rapid diagnosis, triage, isolation, and management of COVID-19 patients with CV complications should be developed and well-rehearsed.
T130 972-1140 Sentence denotes Rapid triaging and management of these patients is crucial, not only to allow efficient utilization of healthcare resources but also to minimize exposure to caregivers.
T131 1141-1295 Sentence denotes There are already reports highlighting delays in delivering acute cardiac care due to extra precautions that need to be observed in view of COVID-19 [14].
T132 1296-1343 Sentence denotes Efforts should be made to minimize such delays.
T133 1344-1346 Sentence denotes 3.
T134 1347-1487 Sentence denotes Strong emphasis should be placed on avoiding unwarranted diagnostic tests (e.g. cardiac troponin, echocardiography, etc.) in these patients.
T135 1488-1721 Sentence denotes This is required to minimize unwarranted downstream diagnostic/therapeutic procedures which would further strain the already stretched healthcare resources and would also subject caregivers to added risk of exposure to the infection.
T136 1722-1884 Sentence denotes The American College of Cardiology has released an advisory discouraging random measurement of cardiac biomarkers such as troponins and natriuretic peptides [15].
T137 1885-2049 Sentence denotes It urges all the clinicians to reserve these assays for circumstances in which they would actually meaningfully add to the management of the patients with COVID-19.
T138 2050-2187 Sentence denotes The American Society of Echocardiography has also issued a similar advisory regarding the use of echocardiography in these patients [16].
T139 2188-2190 Sentence denotes 4.
T140 2191-2402 Sentence denotes The individual hospitals may also have to reconsider risk-benefit ratio of primary percutaneous intervention vs fibrinolysis in patients with COVID-19 who present with ST-segment elevation myocardial infarction.
T141 2403-2405 Sentence denotes 5.
T142 2406-2554 Sentence denotes There has been a concern regarding the safety of ACE inhibitors (ACEi) and angiotensin receptor blockers (ARB) during the ongoing COVID-19 pandemic.
T143 2555-2651 Sentence denotes These agents upregulate expression of ACE2 in various tissues, including on cardiomyocytes [17].
T144 2652-2876 Sentence denotes Since SARS-CoV-2 binds to ACE2 to gain entry into human cells, there is a potentially increased risk of developing COVID-19 or developing more severe disease in patients who are already on background treatment with ACEi/ARB.
T145 2877-2967 Sentence denotes However, to date, no experimental or clinical data have emerged to support these concerns.
T146 2968-3044 Sentence denotes At the same time, the risks of discontinuing these therapies are well known.
T147 3045-3223 Sentence denotes Therefore, several leading professional societies have strongly urged to not discontinue clinically-indicated ACEi/ARB therapy in the event the patient develops COVID-19 [18,19].
T148 3224-3226 Sentence denotes 6.
T149 3227-3384 Sentence denotes Clinicians caring for these patients also need to be fully aware of the potential CV side-effects of various therapies used for treating the viral infection.
T150 3385-3546 Sentence denotes Additionally, various anti-retroviral drugs have significant interactions with cardiac drugs, which need to be considered and appropriate dose modification done.
T151 3547-3698 Sentence denotes More recently, chloroquine/hydroxychloroquine and azathioprine have been proposed as potential therapeutic options, based on preliminary evidence [20].
T152 3699-3813 Sentence denotes Both these drugs are known to prolong QT interval and due caution must be exercised when prescribing these agents.
T153 3814-4096 Sentence denotes Their combination is best avoided and even when using chloroquine/hydroxychloroquine alone, daily electrocardiogram for monitoring QT interval is warranted, esp. in patients with hepatic or renal dysfunction and in those receiving another drug with potential to prolong QT interval.