LitCovid-sentences  

PMC:7102662 / 10999-13470 JSONTXT 13 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T93 0-30 Sentence denotes 2.2.1 Acute myocardial injury
T94 31-124 Sentence denotes Acute myocardial injury is the most commonly described CV complication in COVID-19 (Table 1).
T95 125-316 Sentence denotes Different reports have used different definitions for acute myocardial injury, including rise in cardiac enzymes (different biomarkers and cut-offs) and/or electrocardiographic abnormalities.
T96 317-473 Sentence denotes However, an elevation of high-sensitivity cardiac troponin I (cTnI) above 99th percentile upper reference limit is the most commonly used definition.Table 1
T97 474-634 Sentence denotes The overall incidence of acute cardiac injury has been variable but roughly 8–12% of the positive cases are known to develop significant elevation of cTnI [10].
T98 635-904 Sentence denotes The aforementioned meta-analysis of the Chinese studies [4] reported 8% incidence of acute cardiac injury whereas another study including only those patients who had had a definite outcome (death or discharge from hospital) reported 17% incidence of cTnI elevation [5].
T99 905-1066 Sentence denotes Regardless of the actual incidence, acute cardiac injury has been consistently shown to be a strong negative prognostic marker in patients with COVID-19 [5,6,8].
T100 1067-1185 Sentence denotes The patients admitted to ICU or having severe/fatal illness have several-fold higher likelihood of troponin elevation.
T101 1186-1324 Sentence denotes In contrast, the incidence of elevated troponin has been very low (only 1–2%) in patients having mild illness not requiring ICU admission.
T102 1325-1452 Sentence denotes Any of the mechanisms described above can lead to acute cardiac injury and rise in cardiac troponins in patients with COVID-19.
T103 1453-1677 Sentence denotes The relative role of these different mechanisms has not been described but direct (i.e. non-coronary) myocardial injury due to viral myocarditis or the effect of systemic inflammation appear to be the most common mechanisms.
T104 1678-1814 Sentence denotes These observations are supported by a previous autopsy study in patients who had died due to SARS during the Toronto SARS outbreak [11].
T105 1815-1976 Sentence denotes In this study, the viral ribonucleic acid was detected in 35% of the autopsied human heart samples, providing evidence for direct myocardial injury by the virus.
T106 1977-2098 Sentence denotes No study has described the incidence of ST-segment elevation myocardial infarction in COVID-19, but it appears to be low.
T107 2099-2248 Sentence denotes Similarly, the incidence of left ventricular systolic dysfunction, acute left ventricular failure and cardiogenic shock have also not been described.
T108 2249-2333 Sentence denotes Only one Chinese study reported incidence of heart failure in COVID-19 patients [5].
T109 2334-2471 Sentence denotes Heart failure had occurred in 52% of the patients who subsequently died and in 12% of the patients who were discharged from the hospital.