LitCovid-sentences  

PMC:7102662 / 10951-14734 JSONTXT 14 Projects

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Id Subject Object Predicate Lexical cue
T92 0-46 Sentence denotes 2.2 Cardiovascular manifestations of COVID-19
T93 48-78 Sentence denotes 2.2.1 Acute myocardial injury
T94 79-172 Sentence denotes Acute myocardial injury is the most commonly described CV complication in COVID-19 (Table 1).
T95 173-364 Sentence denotes Different reports have used different definitions for acute myocardial injury, including rise in cardiac enzymes (different biomarkers and cut-offs) and/or electrocardiographic abnormalities.
T96 365-521 Sentence denotes However, an elevation of high-sensitivity cardiac troponin I (cTnI) above 99th percentile upper reference limit is the most commonly used definition.Table 1
T97 522-682 Sentence denotes The overall incidence of acute cardiac injury has been variable but roughly 8–12% of the positive cases are known to develop significant elevation of cTnI [10].
T98 683-952 Sentence denotes The aforementioned meta-analysis of the Chinese studies [4] reported 8% incidence of acute cardiac injury whereas another study including only those patients who had had a definite outcome (death or discharge from hospital) reported 17% incidence of cTnI elevation [5].
T99 953-1114 Sentence denotes Regardless of the actual incidence, acute cardiac injury has been consistently shown to be a strong negative prognostic marker in patients with COVID-19 [5,6,8].
T100 1115-1233 Sentence denotes The patients admitted to ICU or having severe/fatal illness have several-fold higher likelihood of troponin elevation.
T101 1234-1372 Sentence denotes In contrast, the incidence of elevated troponin has been very low (only 1–2%) in patients having mild illness not requiring ICU admission.
T102 1373-1500 Sentence denotes Any of the mechanisms described above can lead to acute cardiac injury and rise in cardiac troponins in patients with COVID-19.
T103 1501-1725 Sentence denotes The relative role of these different mechanisms has not been described but direct (i.e. non-coronary) myocardial injury due to viral myocarditis or the effect of systemic inflammation appear to be the most common mechanisms.
T104 1726-1862 Sentence denotes These observations are supported by a previous autopsy study in patients who had died due to SARS during the Toronto SARS outbreak [11].
T105 1863-2024 Sentence denotes In this study, the viral ribonucleic acid was detected in 35% of the autopsied human heart samples, providing evidence for direct myocardial injury by the virus.
T106 2025-2146 Sentence denotes No study has described the incidence of ST-segment elevation myocardial infarction in COVID-19, but it appears to be low.
T107 2147-2296 Sentence denotes Similarly, the incidence of left ventricular systolic dysfunction, acute left ventricular failure and cardiogenic shock have also not been described.
T108 2297-2381 Sentence denotes Only one Chinese study reported incidence of heart failure in COVID-19 patients [5].
T109 2382-2519 Sentence denotes Heart failure had occurred in 52% of the patients who subsequently died and in 12% of the patients who were discharged from the hospital.
T110 2521-2539 Sentence denotes 2.2.2 Arrhythmias
T111 2540-2605 Sentence denotes Both tachy- and brady-arrhythmias are known to occur in COVID-19.
T112 2606-2736 Sentence denotes A study describing clinical profile and outcomes in 138 Chinese patients with COVID-19 reported 16.7% incidence of arrhythmia [8].
T113 2737-2864 Sentence denotes The incidence was much higher (44.4%) in those requiring ICU admission as compared to those not requiring ICU admission (8.9%).
T114 2865-2906 Sentence denotes The type of arrhythmia was not described.
T115 2908-2947 Sentence denotes 2.2.3 Potential long-term consequences
T116 2948-3086 Sentence denotes COVID-19 has emerged only a few months ago and it is too early to predict long-term outcome of the patients who recover from this illness.
T117 3087-3244 Sentence denotes However, some important messages can be gleaned from previous experiences with SARS, caused by SARS-CoV which shares considerable similarity with SARS-CoV-2.
T118 3245-3469 Sentence denotes It was reported that among patients who had recovered from SARS, 68% continued to have abnormalities of lipid metabolism at 12-years follow-up; CV abnormalities were present in 40% and altered glucose metabolism in 60% [12].
T119 3470-3579 Sentence denotes Similar findings have also been reported in patients recovering from other respiratory tract infections [13].
T120 3580-3783 Sentence denotes Considering this, careful follow-up of those recovering from the current COVID-19 would be important to understand the long-term impact of this illness and also to protect these patients from future CVD.