| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T141 |
0-19 |
Sentence |
denotes |
5.3 TNF inhibitors |
| T142 |
20-219 |
Sentence |
denotes |
As previously described, SARS-CoV infection is associated with a downregulation of ACE2 expression coupled with an increased activity of the renin-angiotensin system responsible for lung injury [14]. |
| T143 |
220-408 |
Sentence |
denotes |
Moreover, the viral spike protein is able to induce a TNF-α-converting enzyme (TACE)-dependent shedding of the ACE2 ectodomain, crucial for the penetration of the virus into the cell [99]. |
| T144 |
409-623 |
Sentence |
denotes |
Since this process seems to be strictly coupled to TNFα production, it has been postulated that the use of TNF inhibitors may be effective in reducing both SARS-CoV2 infection and the consequent organ damage [100]. |
| T145 |
624-776 |
Sentence |
denotes |
As a result, a study evaluating adalimumab in COVID-19 infection has recently been registered in the Chinese Clinical Trial Registry (ChiCTR2000030089). |
