| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T99 |
0-101 |
Sentence |
denotes |
NOD-like receptor 3 (NLRP3) inflammasome is part of the innate immune response during lung infection. |
| T100 |
102-220 |
Sentence |
denotes |
The pathogen, including a virus (CoVs has not yet been tested), triggers NLRP3 activation to amplify the inflammation. |
| T101 |
221-309 |
Sentence |
denotes |
There is probably a balance of the protective and damaging actions of NLRP3 in the lung. |
| T102 |
310-503 |
Sentence |
denotes |
Thus, in a mouse experiment, inhibition of NLRP3 in the early phase of infection increased mortality, whereas suppression of NLRP3 at the peak of infection allowed for a protective effect [51]. |
| T103 |
504-584 |
Sentence |
denotes |
This supports the use of melatonin in ALI/ARDS when inflammation is most severe. |
| T104 |
585-734 |
Sentence |
denotes |
Inflammasome NLRP3 is correlated to lung diseases caused by infection, including influenza A virus, syncytial virus, and bacteria [[51], [52], [53]]. |
| T105 |
735-1064 |
Sentence |
denotes |
The efficacy of melatonin in regulating NLRP3 has been proven in radiation-induced lung injury, allergic airway inflammation and oxygen-induced ALI and LPS-induced ALI models, in which melatonin reduced the infiltration of macrophages and neutrophils into the lung in ALI due to the inhibition of NLRP3 inflammasome [4,28,54,55]. |
