LitCovid-sentences  

PMC:7102560 / 9322-11320 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
T123 0-96 Sentence denotes We need better data to determine risk factors and mechanisms that cause SARS-CoV-2 reactivation.
T124 97-256 Sentence denotes The timing of onset of SARS-CoV-2 reactivation can be variable depending upon the host factors, underlying disease and the type of immunosuppressive therapies.
T125 257-343 Sentence denotes In our study, the recovered patients had positive RT-PCR test results 4–17 days later.
T126 344-494 Sentence denotes The key risk factors for reactivation would include 3 categories: (1) host status, (2) virologic factors and (3) type and degree of immunosuppression.
T127 495-578 Sentence denotes Host factors may include sex, older age, type of disease needing immunosuppression.
T128 579-725 Sentence denotes Although we could not identify risk factors for these host factors in the current study, the potential requires further large cohort confirmation.
T129 726-855 Sentence denotes The virologic factors associated with increased risk of reactivation include high baseline SARS-CoV-2 load and variable genotype.
T130 856-1079 Sentence denotes SARS-CoV-2 viral load would also linked to treatment response, disease severity and progression.8 The association of SARS-CoV-2 genotypes and viral load with SARS-CoV-2 reactivation will be an important question to address.
T131 1080-1163 Sentence denotes In our study, all the patients received antiviral therapy (Oseltamivir or Arbidol).
T132 1164-1259 Sentence denotes These cases suggest that SARS-CoV-2 reactivation may occur whatever the antiviral therapy used.
T133 1260-1390 Sentence denotes These host and virologic factors are important considerations that may further increase the likelihood of SARS-CoV-2 reactivation.
T134 1391-1565 Sentence denotes Therefore, the assessment of host as well as virologic risk factors should be important caveats to help decide whether to initiate prophylactic therapy and immunosuppression.
T135 1566-1633 Sentence denotes Immunosuppressive therapies are the commonly used causative agents.
T136 1634-1708 Sentence denotes These agents have a general mechanism that inhibits many immune functions.
T137 1709-1998 Sentence denotes For example, steroid inhibits cell-mediated immunity by suppressing interleukins production which is important for T and B cell proliferation.9 It is thus not surprising that these general immunosuppressive effects result in broad immune dysfunctions and potential SARS-CoV-2 reactivation.