LitCovid-sentences  

PMC:7096774 / 11725-17625 JSONTXT 14 Projects

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Id Subject Object Predicate Lexical cue
T104 0-10 Sentence denotes Discussion
T105 11-139 Sentence denotes In the early phase of the COVID-19 outbreak, confirmed cases outside China were mostly imported among travellers from Wuhan [7].
T106 140-234 Sentence denotes The first case in Finland was detected on 29 January among the first imported cases in Europe.
T107 235-356 Sentence denotes The case presented mild symptoms without pneumonia: runny nose, nausea, high fever, cough, muscular weakness and fatigue.
T108 357-470 Sentence denotes No secondary transmission events were detected despite active follow-up by the Lapland Hospital district and THL.
T109 471-576 Sentence denotes As at 17 March 2020, 358 additional laboratory-confirmed cases of COVID-19 have been detected in Finland.
T110 577-717 Sentence denotes Many of them are travel-related (mostly from northern Italy and Austria) but there is also local transmission from the travel-related cases.
T111 718-965 Sentence denotes The risk of widespread national community transmission of COVID-19 infection in the European Union, European Economic Area and the United Kingdom in the coming weeks is considered high by the European Centre for Disease Prevention and Control [8].
T112 966-1114 Sentence denotes The sequence of the viral genome of the patient was nearly identical to the reference strain from Wuhan, reflecting an early importation from China.
T113 1115-1251 Sentence denotes Later sequence information in Finland (up to 2 March) showed clustering with strains circulating in Italy (see nextstrain.org/ncov) [9].
T114 1252-1526 Sentence denotes Current guidelines from the World Health Organization for testing COVID-19 recommend collection of both acute and convalescent serum samples from patients for serological testing, which can support the identification of the immune response to a specific viral pathogen [10].
T115 1527-1664 Sentence denotes The SARS-CoV-2 nucleic acid has been found also in anal swabs and blood [11], however we did not detect it in serum samples in this case.
T116 1665-1763 Sentence denotes As yet, only limited data are available on antibody responses during SARS-CoV-2 infection [11,12].
T117 1764-1944 Sentence denotes Further studies are needed to better understand the seroprevalence of antibodies to different corona viruses in populations and the role of these antibodies in the risk of disease.
T118 1945-2174 Sentence denotes In accordance with earlier findings [11], we found that both IgM and IgG titres were low or undetectable at on Day 4 (the second day after admission to hospital) yet increasing on Day 9–10, i.e. 5–6 days after the first sampling.
T119 2175-2332 Sentence denotes Using other detection methods beyond IFA as well as recombinant antigens and analysing samples from a larger number of patients will shed more light on this.
T120 2333-2480 Sentence denotes The time of first appearance of anti-SARS-CoV antibodies has ranged from Day 3 to 42 and Day 5 to 47 for IgM and IgG antibodies, respectively [13].
T121 2481-2670 Sentence denotes The WB of the serum sample collected at convalescence showed a prominent response against the N and S protein, confirming their role as main candidate diagnostic targets for antibody tests.
T122 2671-2776 Sentence denotes However, the patient serum appeared to recognise also the E protein and the processed S1 and S2 proteins.
T123 2777-2921 Sentence denotes Although WB detects mainly linear epitopes, the strong antibody response against the S protein correlated well with the results of the MN assay.
T124 2922-3122 Sentence denotes Monitoring of the binding antibodies is suggested to be a more sensitive method than measuring functional neutralising antibodies for serological detection of human coronavirus (hCoV) infections [14].
T125 3123-3213 Sentence denotes However, hCoV OC43 and 229E samples can also cross-react with SARS-CoV ELISA testing [15].
T126 3214-3350 Sentence denotes The SARS-CoV-2 CPE-based MN test using live virus appeared to be very specific, while laborious to conduct requiring a BSL-3 laboratory.
T127 3351-3551 Sentence denotes An increase of at least 4-fold in the neutralising antibodies indicating a positive response was detected at Day 9–10 after the first symptoms and at Day 20, the antibody levels were still increasing.
T128 3552-3716 Sentence denotes Our findings indicate that the MN assay is specific for functional SARS-CoV-2 antibodies and could be applied in surveillance of population immunity for this virus.
T129 3717-3895 Sentence denotes The assay can be used as confirmatory tool for SARS-CoV-2 specificity in the development of more accessible diagnostic tools such as assays based on detecting binding antibodies.
T130 3896-4079 Sentence denotes Previous studies on patients with SARS-CoV infection indicated that the median time for seroconversion was 20 days, by which time 60–75% of patients had IgG against the virus [13,16].
T131 4080-4273 Sentence denotes That IgM and IgG antibodies were present within 2 weeks from the onset of symptoms in our study suggests that early convalescent patients may be suitable sources of therapeutic antibodies [17].
T132 4274-4521 Sentence denotes In accordance with our finding, a recent preprint report on patients admitted to hospital with confirmed SARS-CoV-2 infection in China indicated that the median time to seroconversion was 11–14 days, depending on the immunological assay used [18].
T133 4522-4667 Sentence denotes No neutralising SARS-CoV-2 antibodies were detected in the close contacts nor in the control population samples collected during 2019 in Finland.
T134 4668-4813 Sentence denotes A low prevalence (0.21%) of antibodies against Middle East respiratory syndrome coronavirus was reported in the general population of Qatar [19].
T135 4814-5063 Sentence denotes A meta-analysis of seroprevalence to SARS-CoV among different human populations yielded an overall low seroprevalence (0.10%), although it was slightly higher (0.23%) among healthcare workers and others who had close contact with SARS patients [20].
T136 5064-5150 Sentence denotes Binding and neutralising HCoV antibodies were found to be higher in older adults [14].
T137 5151-5412 Sentence denotes In total 97% and 99% of serum samples from healthy adults had antibodies to HCoV-229E and HCoV-OC43, respectively [21], and 75% and 65% of the children in the age group 2.5–3.5 years were found to be seropositive for, respectively, HCoV-NL63 and HCoV-229E [22].
T138 5413-5672 Sentence denotes While it has been suggested that the late seroconversion in most SARS patients reduces the value of serological assays during the incubation and initial phases of SARS [13], serological testing is suggested for the confirmation of a SARS CoV-2 infection [11].
T139 5673-5900 Sentence denotes After understanding better the kinetics, specificity and sensitivity of the assays in development, the serological testing may help contact tracing of clusters and have a role in diagnosing acute and past SARS-CoV-2 infections.