Id |
Subject |
Object |
Predicate |
Lexical cue |
T2 |
103-111 |
Sentence |
denotes |
Abstract |
T3 |
112-224 |
Sentence |
denotes |
Structure-based stabilization of protein–protein interactions (PPIs) is a promising strategy for drug discovery. |
T4 |
225-359 |
Sentence |
denotes |
However, this approach has mainly focused on the stabilization of native PPIs, and non-native PPIs have received little consideration. |
T5 |
360-537 |
Sentence |
denotes |
Here, we identified a non-native interaction interface on the three-dimensional dimeric structure of the N-terminal domain of the MERS-CoV nucleocapsid protein (MERS-CoV N-NTD). |
T6 |
538-627 |
Sentence |
denotes |
The interface formed a conserved hydrophobic cavity suitable for targeted drug screening. |