| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T16 |
0-103 |
Sentence |
denotes |
Middle East respiratory syndrome coronavirus (MERS-CoV) belongs to the betacoronavirus (β-CoVs) family. |
| T17 |
104-438 |
Sentence |
denotes |
It causes severe respiratory distress with a high mortality rate in humans.12−14 Recently, a closely related novel coronavirus, coronavirus disease 2019 (COVID-19), caused an outbreak of pneumonia in Wuhan, which further underscored the risk of CoVs to the global public health.15,16 However, there is no effective treatment for CoVs. |
| T18 |
439-623 |
Sentence |
denotes |
Thus, there is an urgent need to develop new antiviral agents against CoVs.14,17 MERS-CoV packages its genome in a nucleocapsid (N) protein and forms a ribonucleoprotein (RNP) complex. |
| T19 |
624-682 |
Sentence |
denotes |
The RNP is essential for viral transcription and assembly. |
| T20 |
683-1051 |
Sentence |
denotes |
Several studies suggested that the modulation of CoV N protein oligomerization by small molecules is a feasible antiviral drug development strategy.18,19 The CoV N protein is organized into the N-terminal domain (NTD) and the C-terminal domain (CTD), with both domains participating in RNA binding.20,21 All CoV N-NTD structures are folded in a monomeric conformation. |
| T21 |
1052-1187 |
Sentence |
denotes |
In contrast, the CoV N-CTDs are always dimeric and are responsible for N protein oligomerization via protein–protein interactions.22,23 |
