PMC:7094172 / 22559-24046 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T180 0-71 Sentence denotes Figure 5 Structures of MERS-CoV N-NTD complexed with potent compounds.
T181 72-560 Sentence denotes The structures were solved using HCoV-OC43 N-NTD (PDB:4J3K) as the search model.24 Left panel: (Upper) structural superimposition of the MERS-CoV N-NTD:P1 complex (monomers 1 and 2 are in purple and pink, respectively) and the MERS-CoV N-NTD:P3 complex (monomers 1 and 2 are in brown and green, respectively) with compounds depicted as stick structures. (Lower) Interactions involving vector-fusion residues in the non-native dimer of the apoprotein shown for comparison with (A) and (B).
T182 561-595 Sentence denotes Color is the same as in Figure 1A.
T183 596-680 Sentence denotes Right panel: detailed interactions among MERS-CoV N-NTD and P1 (A, B) and P3 (C, D).
T184 681-791 Sentence denotes Different Fo–Fc maps were contoured at ∼2.5 σ. (A) Detailed stereoview of interactions at the P1-binding site.
T185 792-851 Sentence denotes The color of each monomer is the same as in the left panel.
T186 852-974 Sentence denotes Residues constructing the P1-binding pocket are labeled and showed as sticks. (B) Schematic of P1 bound to MERS-CoV N-NTD.
T187 975-1054 Sentence denotes Hydrophobic contacts between P1 and each monomer are displayed as dashed lines.
T188 1055-1172 Sentence denotes Nonbonding interactions are indicated by cyan arrows. (C) Detailed stereoview of interactions at the P3-binding site.
T189 1173-1232 Sentence denotes The color of each monomer is the same as in the left panel.
T190 1233-1354 Sentence denotes Residues belonging to the P3-binding pocket are labeled and shown as sticks. (D) Schematic of P3 bound to MERS-CoV N-NTD.
T191 1355-1434 Sentence denotes Hydrophobic contacts between P3 and each monomer are displayed as dashed lines.
T192 1435-1487 Sentence denotes Nonbonding interactions are indicated by red arrows.