LitCovid-sentences  

PMC:7081066 / 1341-3222 JSONTXT 13 Projects

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Id Subject Object Predicate Lexical cue
T13 0-12 Sentence denotes Introduction
T14 13-310 Sentence denotes Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV), and the recently identified novel Coronavirus (SARS-CoV-2) belong to the Coronaviridae family, genus Betacoronavirus, that has been related to important epidemiological outbreaks.
T15 311-395 Sentence denotes These are enveloped viruses with a positive-sense single-strand RNA of around 32 Kb.
T16 396-511 Sentence denotes The viral particles contain four main structural proteins: the spike, membrane, envelope protein, and nucleocapsid.
T17 512-654 Sentence denotes The spike protein protrudes from the envelope of the virion and plays a pivotal role in the receptor host selectivity and cellular attachment.
T18 655-825 Sentence denotes Strong scientific evidence showed that SARS and SARS-CoV-2 spike proteins interact with angiotensin-converting enzyme 2 (ACE2) (Chen et al 2020[2]; Wan et al., 2020[16]).
T19 826-963 Sentence denotes Also, other cellular receptors play a secondary role in the viral attachment, as the C-type lectin CD209L, and DC-SIGN binds to SARS-CoV.
T20 964-1259 Sentence denotes However, ACE2 appears to be the key functional receptor for the SARS-CoV (Coutard et al., 2020[3]; Satija and Lal, 2007[12]) and probably for SARS-CoV-2 (Walls et al., 2020[15]) The interaction between the viral protein and its cell membrane receptor is a critical step in the replication cycle.
T21 1260-1345 Sentence denotes Furthermore, the efficiency of viral infection is strongly dependent on this process.
T22 1346-1427 Sentence denotes Several physicochemical factors are associated with protein-protein interactions.
T23 1428-1559 Sentence denotes These factors are determined by the nature of residues and the type of chemical interactions occurring between ligand and receptor.
T24 1560-1725 Sentence denotes Thus, the presence of residues that produce an energetically favored interaction (lower free energy) may drive binding kinetics and finally lead to the fusion event.
T25 1726-1881 Sentence denotes Based on that, this study aimed to evaluate the energetic profile of the interaction between the SARS-CoV-2 spike protein and the human cell receptor ACE2.