| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T84 |
0-117 |
Sentence |
denotes |
Several amino acid substitutions in RBD were identified in the SARS-CoV-2 RBD compared to Bat-SARS-CoVs and SARS-CoV. |
| T85 |
118-264 |
Sentence |
denotes |
Mutations in the spike protein could change the tropism of a virus, including new hosts or increasing viral pathogenesis (Shang et al., 2020[13]). |
| T86 |
265-360 |
Sentence |
denotes |
HIV infection is a good model of change in viral tropism by mutations in the envelope proteins. |
| T87 |
361-467 |
Sentence |
denotes |
These mutations switch co-receptor use (CCR5 to CXCR4) increasing the viral pathogenesis (Mosier 2009[7]). |
| T88 |
468-647 |
Sentence |
denotes |
Interestingly, our data showed that these changes are not only related to the ability of interaction with the human ACE2 receptor but also for improving this receptor recognition. |
| T89 |
648-858 |
Sentence |
denotes |
The presence of two loops around the RBD of SARS-CoV-2 might be promoting the interaction with the ACE2 receptor, improving the binding to this receptor by increasing the number of atoms involved (Tables 1(Tab. |
| T90 |
859-872 |
Sentence |
denotes |
1) and 2(Tab. |
| T91 |
873-877 |
Sentence |
denotes |
2)). |
| T92 |
878-1033 |
Sentence |
denotes |
The amino acid substitutions and the longer capping loops could explain the increase in binding affinities in SARS-CoV-2 compared to SARS-CoV (Table 1(Tab. |
| T93 |
1034-1038 |
Sentence |
denotes |
1)). |
| T94 |
1039-1152 |
Sentence |
denotes |
Higher affinity values might be related to the dynamic of infection and the rapid spread observed for this virus. |
