PMC:7079862 / 2420-10149 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T20 0-305 Sentence denotes With the expanding use of molecular assays, viral pathogens are increasingly detected among critically ill adult patients with respiratory illness; studies have reported a prevalence between 17% and 53% of patients (Table 1), depending on study design, sample type, duration of illness, and assay methods.
T21 306-637 Sentence denotes Common viruses that can cause severe respiratory viral infections (RVIs) include influenza A and B viruses, picornaviruses (rhinovirus, enterovirus [e.g., enterovirus D68]), human coronaviruses (229E, NL63, OC43, HKU1), respiratory syncytial virus (RSV), human metapneumovirus, parainfluenza virus, and adenovirus (Tables 1 and 2).
T22 638-873 Sentence denotes Novel pathogens including zoonotic coronaviruses like the agents causing Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS) and the 2019 novel coronavirus (2019 nCoV) are still being identified (Table 2).
T23 874-977 Sentence denotes Table 1 Prevalence of community-acquired respiratory viral infections (RVIs) in critically ill patients
T24 978-1233 Sentence denotes Study Population Patients (N) Samples Country Assays Overall prevalence or RVI Influenza Picornaviruses (rhinovirus, enterovirus) Human coronaviruses (229E, NL63, OC43, HKU1) Respiratory syncytial virus Human metapneumovirus Parainfluenza virus Adenovirus
T25 1234-1347 Sentence denotes Daubin 2006 IMV for > 48 h 187 TA France Viral culture, IFA, NAAT 32 (17%) Influenza A 7 (4%) Rhinovirus 19 (10%)
T26 1348-1407 Sentence denotes Enterovirus 2 (1%) 1 (0.5%) 2 (1%) 0 (0%) 1 (0.5%) 1 (0.5%)
T27 1408-1541 Sentence denotes Cameron 2006 COPD exacerbation requiring NIV or IMV 105 PS Australia IFA, viral culture, NAAT, serology 46 (43%) Influenza A 14 (13%)
T28 1542-1578 Sentence denotes Influenza B 6 (6%) Rhinovirus 7 (7%)
T29 1579-1634 Sentence denotes Enterovirus 2 (2%) 3 (3%) 7 (7%) 3 (3%) 11 (10%) 0 (0%)
T30 1635-1765 Sentence denotes Schnell 2014 Acute respiratory failure 70, 47 (67%) mechanically ventilated PS, BAL France IFA, NAAT 34 (49%) Influenza A 11 (16%)
T31 1766-1837 Sentence denotes Influenza B 2 (3%) Rhinovirus 6 (9%) 5 (7%) 4 (6%) 4 (6%) 1 (1%) 3 (4%)
T32 1838-1949 Sentence denotes Legoff 2005 Acute pneumonia admitted to ICU 41 BAL France Viral culture, IFA, NAAT 13 (32%) Influenza A 7 (17%)
T33 1950-2010 Sentence denotes Influenza B 1 (2%) 0 (0%) 0 (0%) 2 (5%) 0 (0%) 2 (5%) 2 (5%)
T34 2011-2163 Sentence denotes Wiemken 2013 Severe CAP admitted to ICU 468, 84% adults PS USA NAAT 106 (23%) Influenza 38 (8%) Rhinovirus 40 (9%) 0 (0%0 8 (2%) 15 (3%) 4 (1%) 1 (0.2%)
T35 2164-2249 Sentence denotes Karhu 2014 Severe CAP 49 PS, BAL, TA Finland NAAT 24 (49%) 1 (2%) Rhinovirus 15 (30%)
T36 2250-2303 Sentence denotes Enterovirus 2 (4%) 2 (4%) 1 (2%) 0 (0%) 1 (2%) 4 (8%)
T37 2304-2396 Sentence denotes Tramuto 2016 ILI admitted to ICU 233 PS, BAL Italy NAAT 102 (44%) 57 (24%) Rhinovirus 7 (3%)
T38 2397-2454 Sentence denotes Enterovirus 14 (6%) 11 (5%) 8 (3%) 16 (7%) 16 (7%) 0 (0%)
T39 2455-2617 Sentence denotes Choi 2019a Severe CAP admitted to ICU 1559 PS, BAL Republic of Korea NAAT Not reported 109 (7.0%) Rhinovirus 120 (8%) 56 (4%) 52 (3%) 50 (3%) 71 (5%) Not reported
T40 2618-2720 Sentence denotes Shorr 2018 Severe CAP and HCAP requiring IMV 364 sputum, TA, BAL USA NAAT 65 (18%) Influenza A 12 (3%)
T41 2721-2814 Sentence denotes Influenza B 1 (0.3%) Rhinovirus/Enterovirus 20 (5%) Not reported 11 (3%) 8 (2%) 7 (2%) 6 (2%)
T42 2815-2951 Sentence denotes Legoff 2018 Hematology patients admitted to ICU 747 PS France NAAT 163 (22%) 20 (3%) 92 (12%) 22 (3%) 18 (2%) 4 (0.5%), 12 (2%) 5 (0.6%)
T43 2952-3137 Sentence denotes Voiriot 2016 Severe CAP admitted to ICU 174 PS, TA, BAL France NAAT 93 (53%) Influenza A 32 (18%) Influenza B 6 (3%) Rhinovirus/Enterovirus 22 (13%) 14 (8%) 9 (5%) 12 (7%) 3 (2%) 3 (2%)
T44 3138-3300 Sentence denotes Arabi 2018 Severe acute respiratory infection admitted to ICU 222 PS, TA, BAL Saudi Arabia NAAT 43 (19%) Influenza A 29 (13%) Influenza B 3 (1%) Rhinovirus 9 (4%)
T45 3301-3362 Sentence denotes Enterovirus 0 (0%) 5 (2%) 1 (0.5%) 1 (0.5%) 1 (0.5%) 1 (0.5%)
T46 3363-3590 Sentence denotes Overall prevalence is reported here for influenza, picornaviruses (rhinovirus, enterovirus), human coronaviruses (229E, NL63, OC43, HKU1), respiratory syncytial virus, human metapneumovirus, parainfluenza virus, and adenovirus.
T47 3591-3644 Sentence denotes Please refer to the online supplement for references.
T48 3645-3871 Sentence denotes Studies varied in the approach for sampling and in the used assays; in some studies, specimen collection and assays were standardized across all patients, while in other studies, sampling and assays were performed selectively.
T49 3872-3968 Sentence denotes All percentages represent % of patients; some patients had more than one viral pathogen isolated
T50 3969-4451 Sentence denotes IMV invasive mechanical ventilation, TA tracheal aspirate, IFA immunofluorescence assay, NAAT (nucleic acid amplification test) includes commercial and in-house PCR, RT-PCR, and PCR multiplex, COPD chronic obstructive pulmonary disease, NIV non-invasive ventilation, PS nasopharyngeal specimen including nasopharyngeal or oropharyngeal aspirates or swabs, BAL bronchoalveolar lavage, CAP community-acquired pneumonia, ILI influenza-like illness, HCAP healthcare-associated pneumonia
T51 4452-4502 Sentence denotes aMultiple publications exist from the same cohort.
T52 4503-4561 Sentence denotes We included the most recent one (Supplementary references)
T53 4562-4678 Sentence denotes Table 2 Common and uncommon community-acquired respiratory viruses that may cause severe respiratory viral infection
T54 4679-4762 Sentence denotes Virus Epidemiologic and clinical features Additional infection control precautionsa
T55 4763-4789 Sentence denotes Common respiratory viruses
T56 4790-4882 Sentence denotes Influenza A and influenza B Only influenza type A viruses are known to have caused pandemics
T57 4883-4985 Sentence denotes Currently circulating seasonal influenza A viruses in humans: subtype A(H1N1)pdm09 and A(H3N2) strains
T58 4986-5069 Sentence denotes Currently circulating influenza B viruses: A/Victoria-like, A/Yamagata-like strains
T59 5070-5246 Sentence denotes May be associated with acute myocardial infarction, myocarditis, rhabdomyolysis, acute renal failure, encephalopathy/encephalitis, and other non-pulmonary complications Droplet
T60 5247-5375 Sentence denotes Picornaviruses (rhinovirus, enterovirus) Frequently detected in critically ill patients with severe acute respiratory infection.
T61 5376-5473 Sentence denotes May cause severe illness in the elderly, persons with co-morbidities including immunosuppression.
T62 5474-5481 Sentence denotes Droplet
T63 5482-5534 Sentence denotes Human coronaviruses (229E, NL63, OC43, HKU1) Contact
T64 5535-5570 Sentence denotes Respiratory syncytial virus Contact
T65 5571-5600 Sentence denotes Human metapneumovirus Contact
T66 5601-5628 Sentence denotes Parainfluenza (1-4) Contact
T67 5629-5659 Sentence denotes Adenoviruses Droplet + contact
T68 5660-5689 Sentence denotes Uncommon and emerging viruses
T69 5690-5797 Sentence denotes Avian influenza A/H5N1, A/H5N6, A/H7N9 and other subtypes Residence in or travel to Southeast and East Asia
T70 5798-5863 Sentence denotes Exposure to poultry or visit to poultry market Airborne + contact
T71 5864-5920 Sentence denotes MERS-CoV Residence in or travel to the Arabian Peninsula
T72 5921-5967 Sentence denotes Exposure to dromedary camel (in endemic areas)
T73 5968-6059 Sentence denotes Nosocomial transmission risk to other patients and to healthcare workers Airborne + contact
T74 6060-6107 Sentence denotes SARS-CoV No cases have been reported since 2004
T75 6108-6199 Sentence denotes Nosocomial transmission risk to other patients and to healthcare workers Airborne + contact
T76 6200-6368 Sentence denotes 2019 Novel coronavirus (2019 nCoV) As of February 4, 2020, 20630 cases were reported from China and 23 other countries Droplet + contact and wherever possible airborneb
T77 6369-6400 Sentence denotes Measlesc Incomplete vaccination
T78 6401-6421 Sentence denotes Characteristic rash.
T79 6422-6527 Sentence denotes Progressive giant cell pneumonia without rash may occur in immunocompromised (Hecht’s pneumonia) Airborne
T80 6528-6644 Sentence denotes Hantaviruses (e.g., Sin Nombre, Andes)c Residence in or travel to affected areas of North, Central, or South America
T81 6645-6720 Sentence denotes Exposure to rodent excretions particularly when cleaning buildings Standard
T82 6721-6778 Sentence denotes Varicella-zoster virusc Incomplete vaccination, pregnancy
T83 6779-6828 Sentence denotes Often with characteristic rash Airborne + contact
T84 6829-6881 Sentence denotes Please refer to the online supplement for references
T85 6882-7350 Sentence denotes Infection control precautions are based on the Centers for Disease Control and Prevention at: https://www.cdc.gov/infectioncontrol/guidelines/isolation/appendix/type-duration-precautions.html#M, https://www.cdc.gov/coronavirus/mers/infection-prevention-control.html, https://www.cdc.gov/infectioncontrol/guidelines/isolation/appendix/standard-precautions.html, https://www.cdc.gov/flu/professionals/infectioncontrol/healthcaresettings.htm (all accessed on Dec 10-2019)
T86 7351-7424 Sentence denotes aAll suspected or confirmed RVIs require minimum of standard precautions.
T87 7425-7577 Sentence denotes Eye protection is a reasonable addition to droplet isolation as the ocular route of infection has been documented for several common respiratory viruses
T88 7578-7667 Sentence denotes bData on the novel coronavirus are based on the WHO interim report as of February 4, 2020
T89 7668-7729 Sentence denotes cOther viral pathogens with respiratory routes of acquisition