LitCovid-sentences  

PMC:7079563 / 15532-20186 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
T117 0-32 Sentence denotes 3.2 Receptor usage of 2019-nCoV
T118 33-114 Sentence denotes The prerequisite of coronaviruses invading the host-cell is to bind to receptors.
T119 115-316 Sentence denotes Following receptor binding, the viral spike protein is cleaved via acid-dependent proteolysis by cathepsin, TMPRRS2 or furin protease, followed by fusion of the viral envelop to the cellular membranes.
T120 317-492 Sentence denotes Spike is a large, clove-shaped trimer, which can be cleaved by proteases into an N-terminal S1 subunit containing the receptor binding domain (RBD) and a C-terminal S2 region.
T121 493-783 Sentence denotes Compared to other proteins of coronavirus, the spike protein has the most variable amino acid sequences which results from the strongest positive selection among all genes of coronavirus to adapt to its hosts [27].The RBD is a major determinant of host range and cross-species transmission.
T122 784-890 Sentence denotes Recently results showed that 2019-nCoV uses the same cell entry receptor, ACE2, as SARS-CoV [21,24,20,28].
T123 891-1017 Sentence denotes Besides human ACE2, 2019-nCoV can use Chinese horseshoe bats, civet, or pig ACE2 but not mouse ACE2 as an entry receptor [24].
T124 1018-1314 Sentence denotes One explanation is that human ACE2 has high homology with Chinese horseshoe bats, civet, pig and mouse, which are 80.75%, 83.48%, 81.37%, 82.11% respectively (Table 2 ), while the residues 82 and 353 of mouse ACE2 are different from human ACE2 which are important residues for bind to spike [29].
T125 1315-1411 Sentence denotes But the homology of human ACE2 and pangolin ACE2, cat ACE2 are also high with 84.84% and 85.22%.
T126 1412-1484 Sentence denotes The homology of human ACE2 with other ACE2 varies from 59.73% to 83.23%.
T127 1485-1538 Sentence denotes In summary, 2019-nCoV may have extensive host ranges.
T128 1539-1547 Sentence denotes Fig. 2 .
T129 1548-1623 Sentence denotes Table 2 The amino acid sequence identities of ACE2 among different species.
T130 1624-1691 Sentence denotes Species Pairwise identities (%) of the amino acid sequences of ACE2
T131 1692-1907 Sentence denotes African green monkey Civet Bat (R. sinicus) Swine Malayan pangolin Mouse Cat Camel Goat Bos mutus Erinaceus europaeus Cavia porcellus Phascolarctos cinereus Sarcophilus harrisii Tiger Snake Parus major Gallus gallus
T132 1908-2015 Sentence denotes Human 93.93 83.48 80.75 81.37 84.84 82.11 85.22 83.23 81.61 81.24 79.01 77.29 71.17 70.51 59.73 67.08 65.31
T133 2016-2131 Sentence denotes African green monkey 81.78 79.93 79.93 83.77 81.78 83.15 81.91 81.41 80.92 77.94 76.85 70.38 69.84 59.21 65.6 64.13
T134 2132-2231 Sentence denotes Civet 81.78 81.49 82.73 85.59 81.61 93.29 83.85 81.86 81.74 79.75 75.55 71.66 71.63 59.6 67.44 66.3
T135 2232-2338 Sentence denotes Bat (R. sinicus) 79.93 81.49 80 82.86 78.26 83.73 81.37 80.37 80 78.51 74.56 69.68 70.02 58.61 65.11 65.19
T136 2339-2435 Sentence denotes Swine 79.93 82.73 80 82.61 80.62 83.98 89.81 87.7 87.58 77.64 75.3 71.17 71.01 61.09 66.95 65.56
T137 2436-2547 Sentence denotes Malayan pangolin 83.77 85.59 82.86 82.61 82.73 87.33 84.72 82.11 81.86 80.87 77.17 71.66 70.89 59.6 67.44 65.07
T138 2548-2648 Sentence denotes Mouse 81.78 81.61 78.26 80.62 82.73 81.74 80.99 80.12 80.37 78.63 78.16 71.05 71.13 61.21 67.2 66.17
T139 2649-2747 Sentence denotes Cat 83.15 93.29 83.73 83.98 87.33 81.74 85.71 83.23 83.11 81.49 76.42 72.65 72.25 59.6 67.81 66.79
T140 2748-2847 Sentence denotes Camel 81.91 83.85 81.37 89.81 84.72 80.99 85.71 88.2 88.57 79.25 77.29 71.79 72.12 61.34 67.2 66.42
T141 2848-2946 Sentence denotes Goat 81.41 81.86 80.37 87.7 82.11 80.12 83.23 88.2 97.76 78.14 76.54 72.04 71.38 60.84 66.09 65.44
T142 2947-3049 Sentence denotes Bos mutus 80.92 81.74 80 87.58 81.86 80.37 83.11 88.57 97.76 78.39 77.04 71.42 71.01 61.09 66.09 65.31
T143 3050-3164 Sentence denotes Erinaceus europaeus 77.94 79.75 78.51 77.64 80.87 78.63 81.49 79.25 78.14 78.39 74.56 70.67 69.65 60.59 68.8 66.42
T144 3165-3274 Sentence denotes Cavia porcellus 76.85 75.55 74.56 75.3 77.17 78.16 76.42 77.29 76.54 77.04 74.56 66.61 66.82 59.38 63.9 63.12
T145 3275-3392 Sentence denotes Phascolarctos cinereus 70.38 71.66 69.68 71.17 71.66 71.05 72.65 71.79 72.04 71.42 70.67 66.61 81.92 60.7 67.08 64.83
T146 3393-3508 Sentence denotes Sarcophilus harrisii 69.84 71.63 70.02 71.01 70.89 71.13 72.25 72.12 71.38 71.01 69.65 66.82 81.92 60.9 64.62 63.84
T147 3509-3610 Sentence denotes Tiger Snake 59.21 59.6 58.61 61.09 59.6 61.21 59.6 61.34 60.84 61.09 60.59 59.38 60.7 60.9 64.5 63.71
T148 3611-3711 Sentence denotes Parus major 65.6 67.44 65.11 66.95 67.44 67.2 67.81 67.2 66.09 66.09 68.8 63.9 67.08 64.62 64.5 82.2
T149 3712-3819 Sentence denotes Gallus gallus 64.13 66.3 65.19 65.56 65.07 66.17 66.79 66.42 65.44 65.31 66.42 63.12 64.83 63.84 63.71 82.2
T150 3820-4316 Sentence denotes Accession numbers: human (NP_068576.1), monkey (AY996037.1), civet (AAX63775.1), bat (R.sinicus) (AGZ48803.1), swine (NP_001116542.1), Malayan pangolin (XP_017505752.1), mouse (NP_001123985.1), cat (NP_001034545.1), camel (XP_010991717.1), goat (NP_001277036.1), Bos mutus (XP_005903173.1), Erinaceus europaeus (XP_007538670.1), Phascolarctos cinereus (XP_020863153.1), Sarcophilus harrisii (XP_031814825.1), tiger Snake (XP_026530754.1), Parus major (XP_015486815.1), Gallus gallus (QEQ50331.1).
T151 4317-4387 Sentence denotes Fig. 2 Phylogenetic analysis of ACE2 from humans and 18 other animals.
T152 4388-4565 Sentence denotes The tree was constructed based on the complete amino acid sequences of ACE2s derived from humans and other animals by using the neighbor-joining (NJ) method with 1000 bootstrap.
T153 4566-4616 Sentence denotes The accession numbers were as the same as Table 2.
T154 4617-4654 Sentence denotes Bootstrap values above 50 were shown.