LitCovid-sentences  

PMC:7077191 / 21579-24510 JSONTXT 13 Projects

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Id Subject Object Predicate Lexical cue
T197 0-5 Sentence denotes 3.10.
T198 6-27 Sentence denotes Pathogenic Mechanisms
T199 28-110 Sentence denotes Many studies have been performed to study the pathogenesis of SARS-CoV [94,95,96].
T200 111-191 Sentence denotes The spike (S) protein and N protein confer stability to the viral particle [97].
T201 192-336 Sentence denotes The N protein is a structural protein involved in virion assembly, and plays a pivotal role in virus transcription and assembly efficiency [97].
T202 337-503 Sentence denotes S protein can bind to the cellular receptors of sensitive cells and mediate infection of their target cells, after which it begins to replicate in the cytoplasm [98].
T203 504-655 Sentence denotes SARS-CoV mainly targets the lungs, immune organs, and small systemic blood vessels and causes systemic vasculitis and decrease of immune function [99].
T204 656-852 Sentence denotes More seriously, the infection leads to extensive pulmonary consolidation, diffuse alveolar damage, and the formation of a transparent membrane, finally deteriorating to respiratory distress [100].
T205 853-1043 Sentence denotes CoV can enter host cells through the interaction between CoV S protein and its host receptor angiotensin-converting enzyme 2 (ACE2), which is isolated from SARS-CoV–permissive Vero-E6 cells.
T206 1044-1129 Sentence denotes The receptor-binding motif (RBM) of S protein can directly contact ACE2 [47,101,102].
T207 1130-1266 Sentence denotes AEC2 have been identified to be key binding residues and functional receptor for SARS-CoV, and it can also protect alveolar cells [103].
T208 1267-1409 Sentence denotes The binding of spike protein to ACE2 and the subsequent downregulation of this receptor contribute to severe alveolar injury during SARS [49].
T209 1410-1746 Sentence denotes The downregulation of ACE2 results in the excessive production of angiotensin II by the related enzyme ACE, and the stimulation of type 1A angiotensin II receptor (AGTR1A) can lead to the increase of pulmonary vascular permeability, which potentially explains the increased lung pathology when the expression of ACE2 is decreased [104].
T210 1747-1833 Sentence denotes ACE2-transfected T cells form multinucleated syncytia with cells expressing S protein.
T211 1834-1936 Sentence denotes The virus was shown to replicate effectively in ACE2-transfected, but not in mock-transfected T cells.
T212 1937-2014 Sentence denotes Antibodies targeting ACE2 can block viral replication in Vero-E6 cells [105].
T213 2015-2173 Sentence denotes Recently, Ji et al. demonstrated that the receptor binding domain of SARS-CoV-2 was capable of binding ACE2 in the context of the SARS-CoV spike protein [51].
T214 2174-2383 Sentence denotes Among SRAS-CoV spike protein’s fourteen residues predicted to interact directly with human ACE2 as the receptor for SARS-CoV, eight amino acids are well conserved in homology SARS-CoV-2 spike protein [26,102].
T215 2384-2527 Sentence denotes At the same time, Wan et al. showed that SARS-CoV-2 uses ACE2 receptors to infect humans, bats, civets, monkeys, and swine, but not mice [106].
T216 2528-2718 Sentence denotes Compared to previously reported SARS-CoV strains, SARS-CoV-2 uses ACE2 receptors more efficiently than human SARS-CoV (year 2003), but less efficiently than human SARS-CoV (year 2002) [106].
T217 2719-2803 Sentence denotes The mutation of proteins determines two important characteristics of the SARS-CoV-2:
T218 2804-2931 Sentence denotes A higher ability to infect and enhanced pathogenicity than the bat-like SARS-CoV, but a lower pathogenicity than SARS-CoV [43].