LitCovid-sentences  

PMC:7077191 / 13057-17255 JSONTXT 13 Projects

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Id Subject Object Predicate Lexical cue
T124 0-4 Sentence denotes 3.7.
T125 5-41 Sentence denotes Prevention, Diagnosis, and Treatment
T126 43-49 Sentence denotes 3.7.1.
T127 50-60 Sentence denotes Prevention
T128 61-210 Sentence denotes As the number of COVID-19 patients in China has been growing rapidly, preventing the spread of SARS-CoV-2 is the most important and urgent task [57].
T129 211-395 Sentence denotes It was shown that human-to-human transmission of SARS-CoV-2 has spread via droplets or close contacts [58,59], but aerosol and fecal-oral transmission still need further study [60,61].
T130 396-470 Sentence denotes To reduce virus transmission, early detection and isolation are essential.
T131 471-542 Sentence denotes In addition, close monitoring in crowded places is also important [62].
T132 543-627 Sentence denotes The possible pathogens of SARS and COVID-19 are both derived from wild animals [63].
T133 628-776 Sentence denotes Therefore, hunting, selling, and eating wild animals not only seriously damage the ecosystem, but also lead to the spread of epidemic diseases [64].
T134 777-862 Sentence denotes Thus, banning all wildlife trade is an effective measure to prevent viral prevalence.
T135 863-968 Sentence denotes Wearing level-D protective clothing can protect medical staff from infection of respiratory viruses [65].
T136 969-1050 Sentence denotes A vaccine against SARS-CoV has not been described in any published articles [66].
T137 1051-1067 Sentence denotes However, on Jan.
T138 1068-1142 Sentence denotes 26th, 2020, the China CDC started to develop a new vaccine for SARS-CoV-2.
T139 1143-1225 Sentence denotes The virus has been successfully isolated and seed strains have been screened [67].
T140 1227-1233 Sentence denotes 3.7.2.
T141 1234-1243 Sentence denotes Diagnosis
T142 1244-1429 Sentence denotes The early symptoms of SARS and COVID-19 are very similar to winter influenza, and the most important way to distinguish flu and pneumonia is to take throat swabs for viral testing [68].
T143 1430-1639 Sentence denotes Current diagnostic tests for coronavirus include RT-PCR, real-time reverse transcription PCR (rRT-PCR), reverse transcription loop-mediated isothermal amplification, as well as real-time RT-LAMP [69,70,71,72].
T144 1640-1802 Sentence denotes National Medical Products Administration has approved seven new nucleic acid test reagents for coronavirus, which were developed based on fluorescence PCR by Feb.
T145 1803-1818 Sentence denotes 1st, 2020 [73].
T146 1819-1969 Sentence denotes Suspected infections can be detected accurately and quickly for timely isolation and treatment to avoid infecting others by using these test reagents.
T147 1971-1977 Sentence denotes 3.7.3.
T148 1978-1987 Sentence denotes Treatment
T149 1988-2103 Sentence denotes Both SARS-CoV and SARS-CoV-2 are CoVs; hence, the treatment strategies of SARS could be relevant for COVID-19 [74].
T150 2104-2288 Sentence denotes In 2003, SARS was mainly treated by isolation of the patients, hormones treatment, antiviral and symptomatic treatments, and many drugs such as glucocorticoid [29] and interferon [75].
T151 2289-2391 Sentence denotes Now, isolation, antiviral, and symptomatic treatments are still mainly adopted for COVID-19 treatment.
T152 2392-2486 Sentence denotes As effective drugs for SARS, hormones and interferons can also be used to treat COVID-19 [74].
T153 2487-2588 Sentence denotes Lopinavir is one kind of protease inhibitor used to treat HIV infection, with ritonavir as a booster.
T154 2589-2655 Sentence denotes Lopinavir and/or ritonavir has anti coronavirus activity in vitro.
T155 2656-2871 Sentence denotes Hong Kong scholars found that, compared with ribavirin alone, patients treated with lopinavir/ritonavir and ribavirin had lower risk of acute respiratory distress syndrome (ARDS) or death caused by SARS-CoV [76,77].
T156 2872-3073 Sentence denotes Lopinavir/ritonavir has also been clinically tested in treatment of COVID-19, and showed wonderfully effective treatment for some patients, but the general clinical effect has not been determined [78].
T157 3074-3139 Sentence denotes More effective treatments are still under continuing exploration:
T158 3140-3147 Sentence denotes On Jan.
T159 3148-3388 Sentence denotes 25th, 2020, a joint research team from the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, and Shanghai Tech University screened and identified 30 potential drugs that are reported to be effective against SARS-CoV-2 [79].
T160 3389-3638 Sentence denotes A high-resolution crystal structure of SARS-CoV-2 coronavirus 3CL hydrolase (Mpro) was announced after the outbreak of COVID-19 in the world [80], and human coronaviruses (HCoVs) have been treated as severe pathogens in respiratory tract infections.
T161 3639-3725 Sentence denotes Nelfinavir was predicted to be a potential inhibitor of SARS-CoV-2 main protease [81].
T162 3726-3892 Sentence denotes The first patient in the US had been trial-treated with intravenous remdesivir (a novel nucleotide analogue prodrug in development) due to a severe infection [82,83].
T163 3893-4013 Sentence denotes No adverse reactions were observed during the administration, and the patient’s condition was effectively improved [84].
T164 4014-4090 Sentence denotes Clinical trials of remdesivir for treatment of COVID-19 just started on Feb.
T165 4091-4198 Sentence denotes 5th and 12th, 2020 in Wuhan and Beijing, respectively, and the experimental results remain unclear [85,86].