LitCovid-sentences  

PMC:7075884 / 1855-4343 JSONTXT 13 Projects

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Id Subject Object Predicate Lexical cue
T14 0-12 Sentence denotes Introduction
T15 13-100 Sentence denotes Ginkgolic acids are alkylphenol constituents of the leaves and fruits of Ginkgo biloba.
T16 101-225 Sentence denotes Ginkgo biloba extracts (GBE) have been used as herbal supplements since at least the 16th century and remain widely in use1.
T17 226-393 Sentence denotes Major constituents of GBE include terpine trilactones (ginkgolide A, B, C, J, and bilobalide), flavonoid glycosides (quercetin and rutin), as well as Ginkgolic acids2.
T18 394-534 Sentence denotes Ginkgolic acids are a mixture of several 2-hydroxy-6-alkylbenzoic acids in which the most common alkyl chains contain 13, 15, or 17 carbons.
T19 535-615 Sentence denotes The 15 and 17 carbon chains are unsaturated at positions 8 and 10, respectively.
T20 616-716 Sentence denotes The 3 Ginkgolic acid (GA) structures are, therefore, designated C13:0, C15:1, and C17:1 (Table S1)3.
T21 717-1042 Sentence denotes GA has shown pleiotropic effects in vitro, including: antitumor effects through inhibition of lipogenesis; decreased expression of invasion associated proteins through AMPK activation; potential rescue of amyloid-β (Aβ) induced synaptic impairment; and inhibition of HIV protease activity as well as HIV viral replication4–7.
T22 1043-1133 Sentence denotes GA was also reported to have activity against Escherichia coli and Staphylococcus aureus8.
T23 1134-1397 Sentence denotes Several ways in which GA works have been suggested including by SUMOylation inhibition activity; blocking formation of the E1-SUMO intermediate9; inhibition of fatty acid synthase10; non-specific SIRT inhibition11; and activation of protein phosphatase type-2C12.
T24 1398-1580 Sentence denotes Here we report that GA shows antiviral activity against Herpes simplex virus 1 (HSV-1), Human cytomegalovirus (HCMV), and Zika virus (ZIKV) primarily through viral fusion inhibition.
T25 1581-1674 Sentence denotes In addition, we show inhibition of entry of a replication-defective non-enveloped adenovirus.
T26 1675-1741 Sentence denotes The antiviral effects were observed below the cytotoxic threshold.
T27 1742-2014 Sentence denotes We believe that broad spectrum antiviral activity is achieved through the inhibition of viral entry and that this effect could be therapeutically utilized systemically in the context of severe acute viral disease, or topically for the treatment of cutaneous viral lesions.
T28 2015-2381 Sentence denotes We show a broad spectrum of fusion inhibition by GA of all three classes of fusion proteins13 including: pathogenic human enveloped viruses from Class I (ZIKV, HIV, EBOV, and influenza A virus (IAV)), Class II (Venezuelan equine encephalitis virus (VEEV) and Semliki Forest virus (SFV)), and Class III (vesicular stomatitis virus (VSV) and Epstein Barr virus (EBV)).
T29 2382-2488 Sentence denotes Taken together, our experiments suggest that GA inhibits viral entry by blocking the initial fusion event.