| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T146 |
0-201 |
Sentence |
denotes |
Previous studies have confirmed the mammalian target of rapamycin complex 1 (mTORC1) as the key factor in regulating various viruses’ replications, including Andes orthohantavirus and coronavirus48,49. |
| T147 |
202-390 |
Sentence |
denotes |
Sirolimus (Z = –2.35 and GSEA score = 3), an inhibitor of mammalian target of rapamycin (mTOR), was reported to effectively block viral protein expression and virion release effectively50. |
| T148 |
391-502 |
Sentence |
denotes |
Indeed, the latest study revealed the clinical application: sirolimus reduced MERS-CoV infection by over 60%51. |
| T149 |
503-661 |
Sentence |
denotes |
Moreover, sirolimus usage in managing patients with severe H1N1 pneumonia and acute respiratory failure can improve those patients’ prognosis significantly50. |
| T150 |
662-958 |
Sentence |
denotes |
Mercaptopurine (Z = –2.44 and GSEA score = 1), an antineoplastic agent with immunosuppressant property, has been used to treat cancer since the 1950s and expanded its application to several auto-immune diseases, including rheumatoid arthritis, systemic lupus erythematosus, and Crohn’s disease52. |
| T151 |
959-1169 |
Sentence |
denotes |
Mercaptopurine has been reported as a selective inhibitor of both SARS-CoV and MERS-CoV by targeting papain-like protease which plays key roles in viral maturation and antagonism to interferon stimulation53,54. |
| T152 |
1170-1303 |
Sentence |
denotes |
Mechanistically, mercaptopurine potentially target several host proteins in HCoVs, such as JUN, PABPC1, NPM1, and NCL40,55 (Fig. 5d). |
