| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T137 |
0-29 |
Sentence |
denotes |
Angiotensin receptor blockers |
| T138 |
30-142 |
Sentence |
denotes |
Angiotensin receptor blockers (ARBs) have been reported to associate with viral infection, including HCoVs42–44. |
| T139 |
143-261 |
Sentence |
denotes |
Irbesartan (Z = –5.98), a typical ARB, was approved by the FDA for treatment of hypertension and diabetic nephropathy. |
| T140 |
262-415 |
Sentence |
denotes |
Here, network proximity analysis shows a significant association between irbesartan’s targets and HCoV-associated host proteins in the human interactome. |
| T141 |
416-657 |
Sentence |
denotes |
As shown in Fig. 5c, irbesartan targets SLC10A1, encoding the sodium/bile acid cotransporter (NTCP) protein that has been identified as a functional preS1-specific receptor for the hepatitis B virus (HBV) and the hepatitis delta virus (HDV). |
| T142 |
658-720 |
Sentence |
denotes |
Irbesartan can inhibit NTCP, thus inhibiting viral entry45,46. |
| T143 |
721-833 |
Sentence |
denotes |
SLC10A1 interacts with C11orf74, a potential transcriptional repressor that interacts with nsp-10 of SARS-CoV47. |
| T144 |
834-1026 |
Sentence |
denotes |
There are several other ARBs (such as eletriptan, frovatriptan, and zolmitriptan) in which their targets are potentially associated with HCoV-associated host proteins in the human interactome. |
