LitCovid-sentences  

PMC:7073332 / 12242-14735 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T74 0-29 Sentence denotes HCoV–host interactome network
T75 30-261 Sentence denotes To depict the HCoV–host interactome network, we assembled the CoV-associated host proteins from four known HCoVs (SARS-CoV, MERS-CoV, HCoV-229E, and HCoV-NL63), one mouse MHV, and one avian IBV (N protein) (Supplementary Table S3).
T76 262-358 Sentence denotes In total, we obtained 119 host proteins associated with CoVs with various experimental evidence.
T77 359-494 Sentence denotes Specifically, these host proteins are either the direct targets of HCoV proteins or are involved in crucial pathways of HCoV infection.
T78 495-549 Sentence denotes The HCoV–host interactome network is shown in Fig. 3a.
T79 550-688 Sentence denotes We identified several hub proteins including JUN, XPO1, NPM1, and HNRNPA1, with the highest number of connections within the 119 proteins.
T80 689-909 Sentence denotes KEGG pathway enrichment analysis revealed multiple significant biological pathways (adjusted P value < 0.05), including measles, RNA transport, NF-kappa B signaling, Epstein-Barr virus infection, and influenza (Fig. 3b).
T81 910-1260 Sentence denotes Gene ontology (GO) biological process enrichment analysis further confirmed multiple viral infection-related processes (adjusted P value < 0.001), including viral life cycle, modulation by virus of host morphology or physiology, viral process, positive regulation of viral life cycle, transport of virus, and virion attachment to host cell (Fig. 3c).
T82 1261-1407 Sentence denotes We then mapped the known drug–target network (see Materials and methods) into the HCoV–host interactome to search for druggable, cellular targets.
T83 1408-1558 Sentence denotes We found that 47 human proteins (39%, blue nodes in Fig. 3a) can be targeted by at least one approved drug or experimental drug under clinical trials.
T84 1559-1642 Sentence denotes For example, GSK3B, DPP4, SMAD3, PARP1, and IKBKB are the most targetable proteins.
T85 1643-1856 Sentence denotes The high druggability of HCoV–host interactome motivates us to develop a drug repurposing strategy by specifically targeting cellular proteins associated with HCoVs for potential treatment of 2019-nCoV/SARS-CoV-2.
T86 1857-1922 Sentence denotes Fig. 3 Drug-target network analysis of the HCoV–host interactome.
T87 1923-1977 Sentence denotes a A subnetwork highlighting the HCoV–host interactome.
T88 1978-2235 Sentence denotes Nodes represent three types of HCoV-associated host proteins: targetgable (proteins can be targeted by approved drugs or drugs under clinical trials), non-targetable (proteins do not have any known ligands), neighbors (protein–protein interaction partners).
T89 2236-2357 Sentence denotes Edge colors indicate five types of experimental evidence of the protein–protein interactions (see Materials and methods).
T90 2358-2493 Sentence denotes 3D three-dimensional structure. b, c KEGG human pathway (b) and gene ontology enrichment analyses (c) for the HCoV-associated proteins.