LitCovid-sentences  

PMC:7068984 / 3280-5905 JSONTXT 12 Projects

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Id Subject Object Predicate Lexical cue
T22 0-151 Sentence denotes The SARS-CoV-2 is a β-coronavirus, which is enveloped non-segmented positive-sense RNA virus (subgenus sarbecovirus, Orthocoronavirinae subfamily) [6].
T23 152-309 Sentence denotes Coronaviruses (CoV) are divided into four genera, including α−/β−/γ−/δ-CoV. α- and β-CoV are able to infect mammals, while γ- and δ-CoV tend to infect birds.
T24 310-554 Sentence denotes Previously, six CoVs have been identified as human-susceptible virus, among which α-CoVs HCoV-229E and HCoV-NL63, and β-CoVs HCoV-HKU1 and HCoV-OC43 with low pathogenicity, cause mild respiratory symptoms similar to a common cold, respectively.
T25 555-675 Sentence denotes The other two known β-CoVs, SARS-CoV and MERS-CoV lead to severe and potentially fatal respiratory tract infections [7].
T26 676-813 Sentence denotes It was found that the genome sequence of SARS-CoV-2 is 96.2% identical to a bat CoV RaTG13, whereas it shares 79.5% identity to SARS-CoV.
T27 814-1032 Sentence denotes Based on virus genome sequencing results and evolutionary analysis, bat has been suspected as natural host of virus origin, and SARS-CoV-2 might be transmitted from bats via unknown intermediate hosts to infect humans.
T28 1033-1189 Sentence denotes It is clear now that SARS-CoV-2 could use angiotensin-converting enzyme 2 (ACE2), the same receptor as SARS-CoV [8], to infect humans (upper panel, Fig. 1).
T29 1190-1266 Sentence denotes Fig. 1 Viral and host factors that influence the pathogenesis of SARS-CoV-2.
T30 1267-1407 Sentence denotes Bats are the reservoir of a wide variety of coronaviruses, including severe acute respiratory syndrome coronavirus (SARS-CoV) -like viruses.
T31 1408-1515 Sentence denotes SARS-CoV-2 may originate from bats or unknown intermediate hosts and cross the species barrier into humans.
T32 1516-1575 Sentence denotes Virus-host interactions affect viral entry and replication.
T33 1576-1588 Sentence denotes Upper panel:
T34 1589-1602 Sentence denotes Viral factor.
T35 1603-1679 Sentence denotes SARS-CoV-2 is an enveloped positive single-stranded RNA (ssRNA) coronavirus.
T36 1680-1805 Sentence denotes Two-thirds of viral RNA, mainly located in the first open reading frame (ORF 1a/b), encodes 16 non-structure proteins (NSPs).
T37 1806-2032 Sentence denotes The rest part of the virus genome encodes four essential structural proteins, including spike (S) glycoprotein, small envelope (E) protein, matrix (M) protein, and nucleocapsid (N) protein, and also several accessory proteins.
T38 2033-2172 Sentence denotes S glycoprotein of SARS-CoV-2 binds to host cell receptors, angiotensin-converting enzyme 2 (ACE2), that is a critical step for virus entry.
T39 2173-2275 Sentence denotes The possible molecules facilitated membrane invagination for SARS-CoV-2 endocytosis are still unclear.
T40 2276-2328 Sentence denotes Other virus proteins may contribute to pathogenesis.
T41 2329-2427 Sentence denotes Host factors (Lower panel) can also influence susceptibility to infection and disease progression.
T42 2428-2550 Sentence denotes The elderly and people with underlying disease are susceptible to SARS-CoV-2 and tend to develop into critical conditions.
T43 2551-2625 Sentence denotes RBD, receptor-binding domain; HR1, heptad repeats 1; HR2, heptad repeats 2