PMC:7068164 / 3319-9727 JSONTXT 13 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T24 0-50 Sentence denotes Epidemiology of first cases in the European Region
T25 51-192 Sentence denotes As at 09:00 on 21 February 2020, 47 confirmed cases of COVID-19 were reported in the WHO European Region and one of these cases had died [4].
T26 193-295 Sentence denotes Data on 38 of these cases (i.e. all except the nine reported in the UK) are included in this analysis.
T27 296-439 Sentence denotes The first three cases detected were reported in France on 24 January 2020 and had onset of symptoms on 17, 19 and 23 January respectively [10].
T28 440-494 Sentence denotes The first death was reported on 15 February in France.
T29 495-557 Sentence denotes As at 21 February, nine countries had reported cases (Figure):
T30 558-694 Sentence denotes Belgium (1), Finland (1), France (12), Germany (16), Italy (3), Russia (2), Spain (2), Sweden (1) and the UK (9 – not included further).
T31 695-851 Sentence denotes Figure Epidemic curve of reported COVID-19 cases by date of symptom onset, or date of notification, WHO European Region, as at 21 February 2020 (n = 38)a,b
T32 852-892 Sentence denotes COVID-19: coronavirus disease 2019; WHO:
T33 893-919 Sentence denotes World Health Organization.
T34 920-1012 Sentence denotes a Four cases were reported by Germany with unknown date of onset and unknown symptomatology.
T35 1013-1068 Sentence denotes Belgium and France reported one asymptomatic case each.
T36 1069-1135 Sentence denotes These cases are displayed according to their date of notification.
T37 1136-1208 Sentence denotes b The figure does not include nine cases reported in the United Kingdom.
T38 1209-1516 Sentence denotes The place of infection (assessed at national level based on an incubation period presumed to be up to 14 days [11], travel history and contact with probable or confirmed cases as per the case definition) was reported for 35 cases (missing for three cases), of whom 14 were infected in China (Hubei province:
T39 1517-1595 Sentence denotes 10 cases; Shandong province: one case; province not reported for three cases).
T40 1596-1643 Sentence denotes The remaining 21 cases were infected in Europe.
T41 1644-1758 Sentence denotes Of these, 14 were linked to a cluster in Bavaria, Germany, and seven to a cluster in Haute-Savoie, France [12,13].
T42 1759-1909 Sentence denotes Cases from the Bavarian cluster were reported from Germany and Spain, whereas cases from the Haute-Savoie cluster were reported from France and Spain.
T43 1910-2086 Sentence denotes Cases linked to the Haute Savoie cluster were also detected in the UK, including the index case of this cluster, who was infected in Singapore before travelling to France [14].
T44 2087-2172 Sentence denotes The index cases for the cluster in Bavaria was reported to be infected in China [15].
T45 2173-2224 Sentence denotes The median age of the 38 cases was 42 years (range:
T46 2225-2262 Sentence denotes 2–81 years) and 25 were male (Table).
T47 2263-2503 Sentence denotes The proportion of male cases was higher among cases acquired in Europe (14 males of 21 cases) compared with those acquired in China (8 males of 14 cases) although the difference was not statistically significant (chi-squared test: p = 0.6).
T48 2504-2556 Sentence denotes There was no difference in median age by sex (males:
T49 2557-2575 Sentence denotes 45 years; females:
T50 2576-2691 Sentence denotes 38 years, k-sample median test, p = 1.0) or by whether infection was acquired in Europe or not (acquired in Europe:
T51 2692-2720 Sentence denotes 47 years; acquired in China:
T52 2721-2740 Sentence denotes 38 years, p = 0.2).
T53 2741-2846 Sentence denotes Table Characteristics of confirmed COVID-19 cases, WHO European Region, as at 21 February 2020 (n = 38)a
T54 2847-2968 Sentence denotes Characteristics Number of cases overall Number of cases infected in Europe Number of cases infected in China p valueb
T55 2969-2987 Sentence denotes Age range in years
T56 2988-3011 Sentence denotes     0–17 4 3 0 0.08
T57 3012-3032 Sentence denotes     18–49 24 13 9
T58 3033-3051 Sentence denotes     50–64 7 5 2
T59 3052-3069 Sentence denotes     ≥ 65 3 0 3
T60 3070-3073 Sentence denotes Sex
T61 3074-3098 Sentence denotes     Male 25 14 8 0.6
T62 3099-3119 Sentence denotes     Female 13 7 6
T63 3120-3132 Sentence denotes Hospitalised
T64 3133-3156 Sentence denotes     Yes 35 21 14 ND
T65 3157-3174 Sentence denotes     No 2 ND ND
T66 3175-3197 Sentence denotes     Unknown 1 ND ND
T67 3198-3245 Sentence denotes Symptomsc (31 cases with available information)
T68 3246-3277 Sentence denotes     Asymptomatic 2 ND ND ND
T69 3278-3299 Sentence denotes     Fever 20 ND ND
T70 3300-3321 Sentence denotes     Cough 14 ND ND
T71 3322-3345 Sentence denotes     Weakness 8 ND ND
T72 3346-3370 Sentence denotes     Headaches 6 ND ND
T73 3371-3397 Sentence denotes     Sore throat 2 ND ND
T74 3398-3424 Sentence denotes     Rhinorrhoea 2 ND ND
T75 3425-3459 Sentence denotes     Shortness of breath 2 ND ND
T76 3460-3528 Sentence denotes Mean days from onset to hospitalisation(29 cases) 3.7 4.6 2.5 ND
T77 3529-3612 Sentence denotes Mean days from onset to first positive laboratory test(16 cases) 5.1 6.5 5.2 ND
T78 3613-3682 Sentence denotes COVID-19: coronavirus disease 2019; ND: not determined or known; WHO:
T79 3683-3709 Sentence denotes World Health Organization.
T80 3710-3781 Sentence denotes a The Table does not include nine cases reported in the United Kingdom.
T81 3782-3894 Sentence denotes b Chi-squared test for difference in distributions between cases infected in Europe and those infected in China.
T82 3895-3944 Sentence denotes c A single case could have more than one symptom.
T83 3945-3995 Sentence denotes Only symptoms reported by two or more cases shown.
T84 3996-4204 Sentence denotes All but two cases were hospitalised (35 of 37 where information on hospitalisation was reported), although it is likely that most were hospitalised to isolate the person rather than because of severe disease.
T85 4205-4349 Sentence denotes The time from onset of symptoms to hospitalisation (and isolation) ranged between 0 and 10 days with a mean of 3.7 days (reported for 29 cases).
T86 4350-4479 Sentence denotes The mean number of days to hospitalisation was 2.5 days for cases imported from China, but 4.6 days for those infected in Europe.
T87 4480-4588 Sentence denotes This was mostly a result of delays in identifying the index cases of the two clusters in France and Germany.
T88 4589-4777 Sentence denotes In the German cluster, for example, the first three cases detected locally were hospitalised in a mean of 5.7 days, whereas the following six took only a mean of 2 days to be hospitalised.
T89 4778-4840 Sentence denotes Symptoms at the point of diagnosis were reported for 31 cases.
T90 4841-4907 Sentence denotes Two cases were asymptomatic and remained so until tested negative.
T91 4908-5027 Sentence denotes The asymptomatic cases were tested as part of screening following repatriation and during contact tracing respectively.
T92 5028-5114 Sentence denotes Of the remaining 29, 20 reported fever, 14 reported cough and eight reported weakness.
T93 5115-5275 Sentence denotes Additional symptoms reported included headaches (6 cases), sore throat (2), rhinorrhoea (2), shortness of breath (2), myalgia (1), diarrhoea (1) and nausea (1).
T94 5276-5330 Sentence denotes Fever was reported as the sole symptom for nine cases.
T95 5331-5576 Sentence denotes In 16 of 29 symptomatic cases, the symptoms at diagnosis were consistent with the case definition for acute respiratory infection [16], although it is possible that cases presented additional symptoms after diagnosis and these were not reported.
T96 5577-5752 Sentence denotes Data on pre-existing conditions were reported for seven cases; five had no pre-existing conditions while one was reported to be obese and one had pre-existing cardiac disease.
T97 5753-5835 Sentence denotes No data on clinical signs e.g. dyspnea etc. were reported for any of the 38 cases.
T98 5836-5992 Sentence denotes All hospitalised cases had a benign clinical evolution except four, two reported in Italy and two reported in France, all of whom developed viral pneumonia.
T99 5993-6130 Sentence denotes All three cases who were aged 65 years or over were admitted to intensive care and required respiratory support and one French case died.
T100 6131-6245 Sentence denotes The case who died was hospitalised for 21 days and required intensive care and mechanical ventilation for 19 days.
T101 6246-6336 Sentence denotes The duration of hospitalisation was reported for 16 cases with a median of 13 days (range:
T102 6337-6348 Sentence denotes 8–23 days).
T103 6349-6408 Sentence denotes As at 21 February 2020, four cases were still hospitalised.