LitCovid-sentences  

PMC:7067204 / 23422-25671 JSONTXT 12 Projects

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Id Subject Object Predicate Lexical cue
T226 0-24 Sentence denotes RNA secondary structures
T227 25-141 Sentence denotes As shown in Figure 7(A–C), the SARS-CoV 5′-UTR contains SL1, SL2, SL3, SL4, S5, SL5A, SL5B, SL5C, SL6, SL7, and SL8.
T228 142-180 Sentence denotes The SL3 contains trans–cis motif [27].
T229 181-320 Sentence denotes The SL1, SL2, SL3, SL4, S5, SL5A, SL5B, and SL5C structures were similar among the 2019-nCoV, human SARS-CoV and the bat SARS-related ZC45.
T230 321-430 Sentence denotes In the 2019-nCoV, part of the S5 found was inside the orf1a/b (marked in red), which was similar to SARS-CoV.
T231 431-497 Sentence denotes In bat SARS-related CoV ZC45, the S5 was not found inside orf1a/b.
T232 498-584 Sentence denotes The 2019-nCoV had the same SL6, SL7, and SL8 as SARS-CoV, and an additional stem loop.
T233 585-656 Sentence denotes Bat SARS-related CoV ZC45 did not have the SARS-COV SL6-like stem loop.
T234 657-715 Sentence denotes Instead, it possessed two other stem loops in this region.
T235 716-758 Sentence denotes All three strains had similar SL7 and SL8.
T236 759-839 Sentence denotes The bat SARS-like CoV ZC45 also had an additional stem loop between SL7 and SL8.
T237 840-946 Sentence denotes Overall, the 5′-UTR of 2019-nCoV was more similar to that of SARS-CoV than the bat SARS-related CoV ZC 45.
T238 947-1053 Sentence denotes The biological relevance and effects of virulence of the 5′-UTR structures should be investigated further.
T239 1054-1166 Sentence denotes The 2019-nCoV had various 3′-UTR structures, including BSL, S1, S2, S3, S4, L1, L2, L3, and HVR (Figure 7(D–F)).
T240 1167-1251 Sentence denotes The 3′-UTR was conserved among 2019-nCoV, human SARS-CoV and SARS-related CoVs [27].
T241 1252-1261 Sentence denotes Figure 7.
T242 1262-1469 Sentence denotes Secondary structure prediction and comparison in the 5′-untranslated region (UTR) and 3′-UTR using the RNAfold WebServer (with minimum free energy and partition function in Fold algorithms and basic options.
T243 1470-1699 Sentence denotes The SARS 5′- and 3′- UTR was used as a reference to adjust the prediction results.(A) SARS-CoV 5'-UTR; (B) 2019-nCoV (HKU-SZ-005b) 5'-UTR; (C) ZC45 5'-UTR; (D) SARS-CoV 3'-UTR; (E) 2019-nCoV (HKU-SZ-005b) 3'-UTR; (F) ZC45 3'-UTR.
T244 1700-1809 Sentence denotes In summary, 2019-nCoV is a novel lineage B Betacoronavirus closely related to bat SARS-related coronaviruses.
T245 1810-1952 Sentence denotes It also has unique genomic features which deserves further investigation to ascertain their roles in viral replication cycle and pathogenesis.
T246 1953-2072 Sentence denotes More animal sampling to determine its natural animal reservoir and intermediate animal host in the market is important.
T247 2073-2249 Sentence denotes This will shed light on the evolutionary history of this emerging coronavirus which has jumped into human after the other two zoonotic Betacoroanviruses, SARS-CoV and MERS-CoV.