Id |
Subject |
Object |
Predicate |
Lexical cue |
T8 |
0-116 |
Sentence |
denotes |
A mysterious outbreak of atypical pneumonia in late 2019 was traced to a seafood wholesale market in Wuhan of China. |
T9 |
117-260 |
Sentence |
denotes |
Within a few weeks, a novel coronavirus tentatively named as 2019 novel coronavirus (2019-nCoV) was announced by the World Health Organization. |
T10 |
261-411 |
Sentence |
denotes |
We performed bioinformatics analysis on a virus genome from a patient with 2019-nCoV infection and compared it with other related coronavirus genomes. |
T11 |
412-537 |
Sentence |
denotes |
Overall, the genome of 2019-nCoV has 89% nucleotide identity with bat SARS-like-CoVZXC21 and 82% with that of human SARS-CoV. |
T12 |
538-704 |
Sentence |
denotes |
The phylogenetic trees of their orf1a/b, Spike, Envelope, Membrane and Nucleoprotein also clustered closely with those of the bat, civet and human SARS coronaviruses. |
T13 |
705-859 |
Sentence |
denotes |
However, the external subdomain of Spike’s receptor binding domain of 2019-nCoV shares only 40% amino acid identity with other SARS-related coronaviruses. |
T14 |
860-923 |
Sentence |
denotes |
Remarkably, its orf3b encodes a completely novel short protein. |
T15 |
924-1059 |
Sentence |
denotes |
Furthermore, its new orf8 likely encodes a secreted protein with an alpha-helix, following with a beta-sheet(s) containing six strands. |
T16 |
1060-1294 |
Sentence |
denotes |
Learning from the roles of civet in SARS and camel in MERS, hunting for the animal source of 2019-nCoV and its more ancestral virus would be important for understanding the origin and evolution of this novel lineage B betacoronavirus. |
T17 |
1295-1484 |
Sentence |
denotes |
These findings provide the basis for starting further studies on the pathogenesis, and optimizing the design of diagnostic, antiviral and vaccination strategies for this emerging infection. |