LitCovid-sentences  

PMC:7060195 / 5298-7874 JSONTXT 11 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T37 0-143 Sentence denotes The E and M proteins have important functions in the viral assembly of a coronavirus, and the N protein is necessary for viral RNA synthesis13.
T38 144-341 Sentence denotes Deletion of E protein abrogated the virulence of CoVs, and several studies have explored the potential of recombinant SARS-CoV or MERS-CoV with a mutated E protein as live attenuated vaccines13,14.
T39 342-661 Sentence denotes The M protein can augment the immune response induced by N protein DNA vaccine against SARS-CoV;15 however, the conserved N protein across CoV families implies that it is not a suitable candidate for vaccine development, and the antibodies against the N protein of SARS-CoV-2 do not provide immunity to the infection16.
T40 662-749 Sentence denotes The critical glycoprotein S of SARS-CoV-2 is responsible for virus binding and entry16.
T41 750-863 Sentence denotes The S precursor protein of SARS-CoV-2 can be proteolytically cleaved into S1 (685 aa) and S2 (588 aa) subunits10.
T42 864-975 Sentence denotes The S2 protein is well conserved among SARS-CoV-2 viruses and shares 99% identity with that of bat SARS-CoVs10.
T43 976-1103 Sentence denotes The vaccine design based on the S2 protein may boost the broad-spectrum antiviral effect and is worth testing in animal models.
T44 1104-1292 Sentence denotes Antibodies against the conserved stem region of influenza hemagglutinin have been found to exhibit broadly cross-reactive immunity, but are less potent in neutralizing influenza A virus17.
T45 1293-1483 Sentence denotes In contrast, the S1 subunit consists of the receptor-binding domain (RBD), which mediates virus entry into sensitive cells through the host angiotensin-converting enzyme 2 (ACE2) receptor18.
T46 1484-1567 Sentence denotes The S1 protein of 2019-nCoV shares about 70% identity with that of human SARS-CoVs.
T47 1568-1750 Sentence denotes The highest number of variations of amino acids in the RBD is located in the external subdomain, which is responsible for the direct interaction between virus and host receptor10,18.
T48 1751-1857 Sentence denotes Blocking the initial entry of a virus is proposed as a successful strategy in controlling viral infection.
T49 1858-2051 Sentence denotes Based on SARS vaccine development, most vaccine candidates target the S protein, which induces neutralizing antibody responses and stimulates a protective cellular immunity against SARS-CoVs12.
T50 2052-2226 Sentence denotes Bukreyev et al.19 showed that immunization of African green monkeys with the full-length S protein of SARS-CoV protects monkeys from subsequent homologous SARS-CoV challenge.
T51 2227-2374 Sentence denotes Administration of SARS-CoV RBD proteins can also induce highly potent neutralizing antibodies and long-term protective immunity in animal models20.
T52 2375-2576 Sentence denotes Thus, the generation of antibodies targeting the S1 subunit of SARS-CoV-2 would be an important preventive and treatment strategy that can be tested further in suitable models before clinical trials10.