LitCovid-sentences  

PMC:7060195 / 1643-3870 JSONTXT 12 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function

Id Subject Object Predicate Lexical cue
T14 0-228 Sentence denotes The entire virus particle-based preparation of vaccines, including inactivated and attenuated virus vaccines is advisable, because it is based on previous studies about the prevention and control of seasonal influenza vaccines6.
T15 229-369 Sentence denotes The first SARS-CoV-2 (Wuhan-Hu-1) was successfully sequenced and its genomic sequence submitted to GenBank on January 5, 2020 (Accession no.
T16 370-383 Sentence denotes MN908947.3)7.
T17 384-626 Sentence denotes Subsequently large-scale culture of SARS-CoV-2 was quickly performed, and an inactivated virus vaccine could be prepared through the employment of established physical and chemical methods such as UV light, formaldehyde, and β-propiolactone8.
T18 627-936 Sentence denotes The development of attenuated-virus vaccines is also possible by carefully screening the serially propagated SARS-CoV-2 with reduced pathogenesis such as induced minimal lung injury, diminished limited neutrophil influx, and increased anti-inflammatory cytokine expressions compared with the wild-type virus9.
T19 937-1040 Sentence denotes Both inactivated and attenuated virus vaccines have their own disadvantages and side effects (Table 1).
T20 1041-1171 Sentence denotes Alternatively, new vaccine designs based on the putative protective antigen/peptides derived from SARS-CoV-2 should be considered.
T21 1172-1241 Sentence denotes Table 1 Advantages and disadvantages of different vaccine strategies.
T22 1242-1294 Sentence denotes Vaccine strategy Advantages Disadvantages References
T23 1295-1448 Sentence denotes Inactivated virus vaccines Easy to prepare; safety; high-titer neutralizing antibodies Potential inappropriate for highly immunosuppressed individuals 25
T24 1449-1598 Sentence denotes Attenuated virus vaccines Rapid development; induce high immune responses Phenotypic or genotypic reversion possible; can still cause some disease 25
T25 1599-1812 Sentence denotes Subunit vaccines High safety; consistent production; can induce cellular and humoral immune responses; high-titer neutralizing antibodies High cost; lower immunogenicity; require repeated doses and adjuvants 12,14
T26 1813-1935 Sentence denotes Viral vector vaccines Safety; induces high cellular and humoral immune responses Possibly present pre-existing immunity 12
T27 1936-2085 Sentence denotes DNA vaccines Easier to design; high safety; high-titer neutralizing antibodies Lower immune responses in humans; repeated doses may cause toxicity 23
T28 2086-2227 Sentence denotes mRNA vaccines Easier to design; high degree of adaptability; induce strong immune responses Highly unstable under physiological conditions 23