LitCovid-sentences  

PMC:7054527 / 2965-6327 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
T21 0-41 Sentence denotes Characteristics of 2019 novel coronavirus
T22 42-186 Sentence denotes Coronaviruses belong to the family of Coronaviridae, of the order Nidovirales, comprising large, single, plus-stranded RNA as their genome13,14.
T23 187-274 Sentence denotes Currently, there are four genera of coronaviruses: α-CoV, β-CoV, γ-CoV, and δ-CoV15,16.
T24 275-358 Sentence denotes Most of the coronavirus can cause the infectious diseases in human and vertebrates.
T25 359-532 Sentence denotes The α-CoV and β-CoV mainly infect the respiratory, gastrointestinal, and central nervous system of humans and mammals, while γ-CoV and δ-CoV mainly infect the birds13,17–19.
T26 533-796 Sentence denotes Usually, several members of the coronavirus cause mild respiratory disease in humans; however, SARS-CoV and the Middle East respiratory syndrome coronavirus (MERS-CoV) explored in 2002–2003 and in 2012, respectively, caused fatal severe respiratory diseases20–22.
T27 797-848 Sentence denotes The SARS-CoV and MERS-CoV belong to the β-CoV23,24.
T28 849-973 Sentence denotes 2019-nCoV explored in Wuhan also belongs to the β-CoV according to the phylogenetic analysis based on the viral genome10,11.
T29 974-1216 Sentence denotes Although the nucleotide sequence similarity is less than 80% between 2019-nCoV and SARS-CoV (about 79%) or MERS-CoV (about 50%), 2019-nCoV can also cause the fetal infection and spread more faster than the two other coronaviruses7,9,11,25–27.
T30 1217-1478 Sentence denotes The genome nucleotide sequence identity between a coronavirus (BatCoV RaTG13) detected in the bat Rhinolophus affinis from Yunnan Province, China, and 2019-nCoV, was 96.2%, indicating that the natural host of 2019-nCoV may also be the Rhinolophus affinis bat11.
T31 1479-1591 Sentence denotes However, the differences may also suggest that there is an or more intermediate hosts between the bat and human.
T32 1592-1765 Sentence denotes A research team from the South China Agricultural University has invested more than 1 000 metagenomic samples from pangolins, and found that 70% pangolins contained β-CoV28.
T33 1766-2008 Sentence denotes One of the coronaviruses they isolated from the pangolins comprised a genome that was very similar with that from 2019-nCoV, and the genome sequence similarity was 99%, indicating that the pangolin may be the intermediate host of 2019-nCoV29.
T34 2009-2325 Sentence denotes 2019-nCoV possessed the typical coronavirus structure with the “spike protein” in the membrane envelope30, and also expressed other polyproteins, nucleoproteins, and membrane proteins, such as RNA polymerase, 3-chymotrypsin-like protease, papain-like protease, helicase, glycoprotein, and accessory proteins10,11,30.
T35 2326-2444 Sentence denotes The S protein from coronavirus can bind to the receptors of the host to facilitate viral entry into target cells31,32.
T36 2445-2798 Sentence denotes Although there are four amino acid variations of S protein between 2019-nCoV and SARS-CoV, 2019-nCoV can also bind to the human angiotensin-converting enzyme 2 (ACE2), the same host receptor for SARS-CoV, as 2019-nCoV can bind to the ACE2 receptor from the cells from human, bat, civet cat, and pig, but it cannot bind to the cells without ACE211,33–35.
T37 2799-3026 Sentence denotes A recombinant ACE2-Ig antibody, a SARS-CoV-specific human monoclonal antibody, and the serum from a convalescent SARS-CoV-infected patient, which can neutralize 2019-nCoV, confirmed ACE2 as the host receptor for 2019-nCoV36–39.
T38 3027-3192 Sentence denotes The high affinity between ACE2 and 2019-nCoV S protein also suggested that the population with higher expression of ACE2 might be more susceptible to 2019-nCoV40,41.
T39 3193-3362 Sentence denotes The cellular serine protease TMPRSS2 also contributed to the S-protein priming of 2019-nCoV, indicating that the TMPRSS2 inhibitor might constitute a treatment option36.