PMC:7045880 / 10113-12740 JSONTXT 12 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T94 0-10 Sentence denotes Discussion
T95 11-156 Sentence denotes As of February 12th, 2020, 28 cases of COVID-19 have been reported in Korea, with the first case observed in a traveler residing in Wuhan, China.
T96 157-292 Sentence denotes The SARS-CoV-2 was isolated from a Korean patient who had self-administered antipyretics for initial symptoms such as chills and fever.
T97 293-403 Sentence denotes The patient had experienced intermittent coughing with sputum 3 days after the administration of antipyretics.
T98 404-522 Sentence denotes The SARS-CoV-2 could replicate in other cells (Vero E6 and Caco-II cells), in addition to Vero cells (data not shown).
T99 523-692 Sentence denotes The first SARS-CoV-2 was successfully isolated by inoculating human airway epithelial cells with bronchoalveolar-lavage fluid samples from a patient with pneumonia [16].
T100 693-924 Sentence denotes Since human airway epithelial cells (because of their resemblance to pseudostratified mucociliary epithelium) require 4–6 weeks to differentiate in vivo, isolation of SARS-CoV-2 using Vero cells or Caco-II cells is more convenient.
T101 925-1045 Sentence denotes Further studies are needed to select more sensitive cell lines suitable for virus isolation from low viral load samples.
T102 1046-1325 Sentence denotes The sequence of the suspected novel coronavirus (KCDC03) was analyzed using the sequences of 54 SARS-CoV-2 including 6 human coronaviruses, Bat-CoVs, and 51 SARS-CoV-2 that have been registered in GISAID by several countries including China, and a phylogenetic tree was produced.
T103 1326-1452 Sentence denotes Results show that the isolate from Korea was clustered with the new coronavirus, SARS-CoV-2 and classified as betacoronavirus.
T104 1453-1631 Sentence denotes High homology (99.94%–99.99%) was confirmed with the viral sequences reported from other countries, such as those from Wuhan/IVDC-HB-01/2019(GISAID accession ID: EPI_ISL_402119).
T105 1632-1756 Sentence denotes Homology with bat CoV (bat-SL-CoVZC45), SARS-CoV (AY278741) and MERS-CoV (JX869059) was 89.1%, 77.5%, and 50%, respectively.
T106 1757-1983 Sentence denotes However, the lowest homology of 99.5% was observed with BetaCoV/Wuwhan/IVDCHB-04/2020, which could be because of the inaccurate sequence of IVDCHB-04, Hence, it has been excluded from the comparative analysis in other studies.
T107 1984-2147 Sentence denotes Prior to identification of SARS-CoV-2 as the causative agent of the unknown pneumonia in Wuhan, China, pan-CoV RT-PCR was being used to detect SARS-CoV-2 in Korea.
T108 2148-2257 Sentence denotes The Pan-CoV RT-PCR detects all human coronaviruses and animal-derived coronaviruses (personal communication).
T109 2258-2389 Sentence denotes Since the release of the SARS-CoV-2 sequence, a real-time RT-PCR method has been established in the diagnosis of COVID-19 patients.
T110 2390-2475 Sentence denotes Currently, the diagnosis of COVID-19 is based on gene detection via real-time RT-PCR.
T111 2476-2627 Sentence denotes With the isolation of the causative agent, development of serological tests and rapid diagnostic tests in addition to virus detection will be required.