Id |
Subject |
Object |
Predicate |
Lexical cue |
T94 |
0-10 |
Sentence |
denotes |
Discussion |
T95 |
11-156 |
Sentence |
denotes |
As of February 12th, 2020, 28 cases of COVID-19 have been reported in Korea, with the first case observed in a traveler residing in Wuhan, China. |
T96 |
157-292 |
Sentence |
denotes |
The SARS-CoV-2 was isolated from a Korean patient who had self-administered antipyretics for initial symptoms such as chills and fever. |
T97 |
293-403 |
Sentence |
denotes |
The patient had experienced intermittent coughing with sputum 3 days after the administration of antipyretics. |
T98 |
404-522 |
Sentence |
denotes |
The SARS-CoV-2 could replicate in other cells (Vero E6 and Caco-II cells), in addition to Vero cells (data not shown). |
T99 |
523-692 |
Sentence |
denotes |
The first SARS-CoV-2 was successfully isolated by inoculating human airway epithelial cells with bronchoalveolar-lavage fluid samples from a patient with pneumonia [16]. |
T100 |
693-924 |
Sentence |
denotes |
Since human airway epithelial cells (because of their resemblance to pseudostratified mucociliary epithelium) require 4–6 weeks to differentiate in vivo, isolation of SARS-CoV-2 using Vero cells or Caco-II cells is more convenient. |
T101 |
925-1045 |
Sentence |
denotes |
Further studies are needed to select more sensitive cell lines suitable for virus isolation from low viral load samples. |
T102 |
1046-1325 |
Sentence |
denotes |
The sequence of the suspected novel coronavirus (KCDC03) was analyzed using the sequences of 54 SARS-CoV-2 including 6 human coronaviruses, Bat-CoVs, and 51 SARS-CoV-2 that have been registered in GISAID by several countries including China, and a phylogenetic tree was produced. |
T103 |
1326-1452 |
Sentence |
denotes |
Results show that the isolate from Korea was clustered with the new coronavirus, SARS-CoV-2 and classified as betacoronavirus. |
T104 |
1453-1631 |
Sentence |
denotes |
High homology (99.94%–99.99%) was confirmed with the viral sequences reported from other countries, such as those from Wuhan/IVDC-HB-01/2019(GISAID accession ID: EPI_ISL_402119). |
T105 |
1632-1756 |
Sentence |
denotes |
Homology with bat CoV (bat-SL-CoVZC45), SARS-CoV (AY278741) and MERS-CoV (JX869059) was 89.1%, 77.5%, and 50%, respectively. |
T106 |
1757-1983 |
Sentence |
denotes |
However, the lowest homology of 99.5% was observed with BetaCoV/Wuwhan/IVDCHB-04/2020, which could be because of the inaccurate sequence of IVDCHB-04, Hence, it has been excluded from the comparative analysis in other studies. |
T107 |
1984-2147 |
Sentence |
denotes |
Prior to identification of SARS-CoV-2 as the causative agent of the unknown pneumonia in Wuhan, China, pan-CoV RT-PCR was being used to detect SARS-CoV-2 in Korea. |
T108 |
2148-2257 |
Sentence |
denotes |
The Pan-CoV RT-PCR detects all human coronaviruses and animal-derived coronaviruses (personal communication). |
T109 |
2258-2389 |
Sentence |
denotes |
Since the release of the SARS-CoV-2 sequence, a real-time RT-PCR method has been established in the diagnosis of COVID-19 patients. |
T110 |
2390-2475 |
Sentence |
denotes |
Currently, the diagnosis of COVID-19 is based on gene detection via real-time RT-PCR. |
T111 |
2476-2627 |
Sentence |
denotes |
With the isolation of the causative agent, development of serological tests and rapid diagnostic tests in addition to virus detection will be required. |