| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T3 |
0-184 |
Sentence |
denotes |
The ACE2 gene encodes the angiotensin-converting enzyme-2, which has been proved to be the receptor for both the SARS-coronavirus (SARS-CoV) and the human respiratory coronavirus NL63. |
| T4 |
185-309 |
Sentence |
denotes |
Recent studies and analyses indicate that ACE2 could be the host receptor for the novel coronavirus 2019-nCoV/SARS-CoV-21,2. |
| T5 |
310-426 |
Sentence |
denotes |
Previous studies demonstrated the positive correlation of ACE2 expression and the infection of SARS-CoV in vitro3,4. |
| T6 |
427-530 |
Sentence |
denotes |
A number of ACE2 variants could reduce the association between ACE2 and S-protein in SARS-CoV or NL635. |
| T7 |
531-719 |
Sentence |
denotes |
Therefore, the expression level and expression pattern of human ACE2 in different tissues might be critical for the susceptibility, symptoms, and outcome of 2019-nCoV/SARS-CoV-2 infection. |
| T8 |
720-838 |
Sentence |
denotes |
A recent single-cell RNA-sequencing (RNA-seq) analysis indicated that Asian males may have higher expression of ACE26. |
| T9 |
839-964 |
Sentence |
denotes |
Currently, the clinical reports of 2019-nCoV/SARS-CoV-2 infection from non-Asian populations for comparison are very limited. |
| T10 |
965-1080 |
Sentence |
denotes |
A study from Munich reported four German cases, all of which showed mild clinical symptoms without severe illness7. |
| T11 |
1081-1190 |
Sentence |
denotes |
However, the genetic basis of ACE2 expression and function in different populations is still largely unknown. |
| T12 |
1191-1465 |
Sentence |
denotes |
Therefore, genetic analysis of expression quantitative trait loci (eQTLs)8 and potential functional coding variants in ACE2 among populations are required for further epidemiological investigations of 2019-nCoV/SARS-CoV-2 spreading in East Asian (EAS) and other populations. |
