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PMC:7036343 JSONTXT 21 Projects

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Id Subject Object Predicate Lexical cue
T1 0-21 Sentence denotes Letter to the Editor:
T2 22-230 Sentence denotes Case of the Index Patient Who Caused Tertiary Transmission of Coronavirus Disease 2019 in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Pneumonia Monitored by Quantitative RT-PCR
T3 232-522 Sentence denotes I am grateful that Dr. Lim and his colleagues reported a case of COVID-19 that caused tertiary transmission in Korea and added information about the novel infectious disease.1 In this report, the authors emphasized the decrease in viral titer due to the effects of antiviral administration.
T4 523-670 Sentence denotes However, I would like to discuss what to look out for when interpreting the causal relationship between laboratory results and therapeutic effects.
T5 671-934 Sentence denotes Lopinavir and ritonavir (LPV/r) is considered a promising treatment option for COVID-19 based on the 2003 SARS treatment experience.23 However, care should be taken when administering because there are no or little clinical evidence for the new virus, SARS-CoV-2.
T6 935-1217 Sentence denotes I have treated with LPV/r as an antiviral agent in patients with pneumonia caused by COVID-19, but the disease course has not improved dramatically.4 Fortunately, the patient did not develop acute respiratory failure, but it was not clear whether it was an effect of antiviral drug.
T7 1218-1418 Sentence denotes According to the Center for Laboratory Control of Infectious Diseases in KCDC, the upper limit of Ct value for positive RT-PCR of SARS-CoV-2 is 35, and the negative criterion is Ct value 37 or higher.
T8 1419-1578 Sentence denotes In this case report, it is difficult to determine that the test result is positive because the Ct value is 35.66 on day 10, the day of the antiviral treatment.
T9 1579-1641 Sentence denotes If there was a virus, it would have remained a very low titer.
T10 1642-1872 Sentence denotes Since LPV/r was administered during the virus titer reduction from 30.71 (day 9) to 35.66 (day 10), I think two consecutive negative results are more likely to be due to the natural history of the disease than to antiviral agents.
T11 1873-2047 Sentence denotes Furthermore, the authors did not explain why Ct values are consistently detected near positive criteria from day 4 of treatment despite the continued use of antiviral agents.
T12 2048-2166 Sentence denotes The authors say they do not know whether the decrease in virus titer is a natural course or antiviral effect, or both.
T13 2167-2260 Sentence denotes However, the authors are making a leap of logic that LPV/r administration reduces viral load.
T14 2261-2349 Sentence denotes Also, the authors explain that LPV/r administration has also improved clinical symptoms.
T15 2350-2454 Sentence denotes However, The fever has already been falling from the day before, and the cough lasted for few more days.
T16 2455-2582 Sentence denotes Since LPV/r was given to patients on day 10, it could not be regarded as being administered in the early stages of the disease.
T17 2583-2683 Sentence denotes However, the authors argue that antivirals should be given early in the disease, based on this case.
T18 2684-2871 Sentence denotes For the reasons described so far, it is difficult to say that LPV/r lowers the virus level or improves symptoms or is "recommended" for COVID-19 treatment based on this case report alone.
T19 2872-2991 Sentence denotes Regardless of the case report, I still believe that LPV/r is a promising antiviral agent for the treatment of COVID-19.
T20 2992-3140 Sentence denotes However, it is clear that well-designed studies have to be carried out to build more evidence so that they can be recommended as therapeutic agents.
T21 3141-3215 Sentence denotes Research is a very important component of the response during an outbreak.
T22 3216-3381 Sentence denotes But even if the epidemic is underway, we should reiterate that we should try to find evidence based on a scientific background, and be careful to advise what is not.
T23 3383-3394 Sentence denotes Disclosure:
T24 3395-3457 Sentence denotes The author has no potential conflicts of interest to disclose.